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Evidens för trombosprofylax till medicinpatienter med hög risk

Själander, Anders; Jansson, Jan-Åke; Bergqvist, David; Eriksson, Henry and Svensson, Peter LU (2007) In Läkartidningen 104(20-21). p.1585-1587
Abstract
Venous thromboembolism (VTE) is a common complication of hospitalization, and can result in substantial morbidity and treatment cost. In orthopedic and general surgery, it is common practice to use low-molecular-weight heparin as a thromboprophylaxis. For medical patients, however, the issue of prophylaxis remains under debate. Data from three recent large randomized studies of medical patients at risk for VTE: PREVENT, MEDENOX and ARTEMIS, were combined. They showed an absolute risk reduction (ARR) for symptomatic VTE of 0,48 percent, asymptomatic VTE of 2,5 percent with a subsequent increase in major bleedings of 0,38 percent. In most studies, low-molecular-weight heparin reduces the risk of VTE by approximately 45 percent. Thus, the... (More)
Venous thromboembolism (VTE) is a common complication of hospitalization, and can result in substantial morbidity and treatment cost. In orthopedic and general surgery, it is common practice to use low-molecular-weight heparin as a thromboprophylaxis. For medical patients, however, the issue of prophylaxis remains under debate. Data from three recent large randomized studies of medical patients at risk for VTE: PREVENT, MEDENOX and ARTEMIS, were combined. They showed an absolute risk reduction (ARR) for symptomatic VTE of 0,48 percent, asymptomatic VTE of 2,5 percent with a subsequent increase in major bleedings of 0,38 percent. In most studies, low-molecular-weight heparin reduces the risk of VTE by approximately 45 percent. Thus, the prophylaxis may be efficient, but its clinical use is limited to patient populations with a high incidence of VTE. Further studies to identify medical patients who are at high risk and would benefit from prophylaxis are warranted. (Less)
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author
organization
alternative title
Evidence for thrombosis prophylaxis to high-risk patients
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fibrinolytika, Ventrombos, Blodförtunningsmedel, Blodproppssjukdomar
in
Läkartidningen
volume
104
issue
20-21
pages
1585 - 1587
external identifiers
  • pmid:17564265
  • scopus:34249008480
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
b6c5e3fc-0155-438b-b4a2-480ec7062f78 (old id 1139956)
alternative location
http://ltarkiv.lakartidningen.se/artNo33449
date added to LUP
2008-08-21 09:08:02
date last changed
2017-01-01 07:16:04
@article{b6c5e3fc-0155-438b-b4a2-480ec7062f78,
  abstract     = {Venous thromboembolism (VTE) is a common complication of hospitalization, and can result in substantial morbidity and treatment cost. In orthopedic and general surgery, it is common practice to use low-molecular-weight heparin as a thromboprophylaxis. For medical patients, however, the issue of prophylaxis remains under debate. Data from three recent large randomized studies of medical patients at risk for VTE: PREVENT, MEDENOX and ARTEMIS, were combined. They showed an absolute risk reduction (ARR) for symptomatic VTE of 0,48 percent, asymptomatic VTE of 2,5 percent with a subsequent increase in major bleedings of 0,38 percent. In most studies, low-molecular-weight heparin reduces the risk of VTE by approximately 45 percent. Thus, the prophylaxis may be efficient, but its clinical use is limited to patient populations with a high incidence of VTE. Further studies to identify medical patients who are at high risk and would benefit from prophylaxis are warranted.},
  author       = {Själander, Anders and Jansson, Jan-Åke and Bergqvist, David and Eriksson, Henry and Svensson, Peter},
  issn         = {0023-7205},
  keyword      = {Fibrinolytika,Ventrombos,Blodförtunningsmedel,Blodproppssjukdomar},
  language     = {swe},
  number       = {20-21},
  pages        = {1585--1587},
  series       = {Läkartidningen},
  title        = {Evidens för trombosprofylax till medicinpatienter med hög risk},
  volume       = {104},
  year         = {2007},
}