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Retinopathy in subjects with impaired fasting glucose The NANSY – Eye Study, Baseline report

Tyrberg, Maria LU ; Melander, Arne LU ; Lövestam Adrian, Monica LU and Lindblad, Ulf LU (2008) In Diabetes, Obesity and Metabolism 10(8). p.646-651
Abstract
Aims: Network for Pharmacoepidemiology (NEPI) Antidiabetes Study-Eye is a randomized placebo-controlled Swedish trial investigating if treatment with sulphonylurea, in addition to dietary regulation and increased exercise, delays the development of retinopathy in subjects with impaired fasting glucose (IFG).



Methods: Subjects were surveyed in primary care with repeated fasting blood glucose measurements. Those with a mean of two consecutive values ≥5.6 and <6.1 mmol/l were invited to participate. Baseline physical examination included blood pressure and body mass index (BMI). Fundus photos were taken in two fields using 35-mm diafilm. The alternative classification of the Wisconsin Epidemiologic Study of Diabetic... (More)
Aims: Network for Pharmacoepidemiology (NEPI) Antidiabetes Study-Eye is a randomized placebo-controlled Swedish trial investigating if treatment with sulphonylurea, in addition to dietary regulation and increased exercise, delays the development of retinopathy in subjects with impaired fasting glucose (IFG).



Methods: Subjects were surveyed in primary care with repeated fasting blood glucose measurements. Those with a mean of two consecutive values ≥5.6 and <6.1 mmol/l were invited to participate. Baseline physical examination included blood pressure and body mass index (BMI). Fundus photos were taken in two fields using 35-mm diafilm. The alternative classification of the Wisconsin Epidemiologic Study of Diabetic Retinopathy was used to classify the retinopathy level.



Results: At baseline, 90 men and 64 women with IFG were photographed. Of these, 16 subjects (10%) had mild or very mild retinopathy. There was no difference in occurrence of retinopathy between subjects with known diagnosis of hypertension or not. However, subjects with retinopathy had significantly higher systolic (154 vs. 141 mmHg, p = 0.013) and diastolic (86 vs. 81 mmHg, p = 0.008) blood pressure levels independent of differences in age, sex and known hypertension. There was a corresponding difference in BMI, being greater in subjects with than in those without retinopathy (32.4 vs. 29.2 kg/m2, p = 0.013). There were no associations between levels of fasting blood glucose or haemoglobin A1c, on the one hand, and retinopathy, on the other.



Conclusion: Retinopathy may be present even before type 2 diabetes is manifest. It is associated with higher blood pressure levels and higher BMI values, that is, with predominant features of the metabolic syndrome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sulphonylurea, retinopathy, impaired fasting glucose, clinical trial, hypertension
in
Diabetes, Obesity and Metabolism
volume
10
issue
8
pages
646 - 651
publisher
Wiley-Blackwell
external identifiers
  • wos:000257514100005
  • scopus:47949104275
ISSN
1462-8902
DOI
10.1111/j.1463-1326.2007.00759.x
language
English
LU publication?
yes
id
89fb3146-960d-4025-891f-56597e66cec4 (old id 1140072)
date added to LUP
2008-08-21 12:59:33
date last changed
2017-11-12 03:22:05
@article{89fb3146-960d-4025-891f-56597e66cec4,
  abstract     = {Aims: Network for Pharmacoepidemiology (NEPI) Antidiabetes Study-Eye is a randomized placebo-controlled Swedish trial investigating if treatment with sulphonylurea, in addition to dietary regulation and increased exercise, delays the development of retinopathy in subjects with impaired fasting glucose (IFG).<br/><br>
<br/><br>
Methods: Subjects were surveyed in primary care with repeated fasting blood glucose measurements. Those with a mean of two consecutive values ≥5.6 and &lt;6.1 mmol/l were invited to participate. Baseline physical examination included blood pressure and body mass index (BMI). Fundus photos were taken in two fields using 35-mm diafilm. The alternative classification of the Wisconsin Epidemiologic Study of Diabetic Retinopathy was used to classify the retinopathy level.<br/><br>
<br/><br>
Results: At baseline, 90 men and 64 women with IFG were photographed. Of these, 16 subjects (10%) had mild or very mild retinopathy. There was no difference in occurrence of retinopathy between subjects with known diagnosis of hypertension or not. However, subjects with retinopathy had significantly higher systolic (154 vs. 141 mmHg, p = 0.013) and diastolic (86 vs. 81 mmHg, p = 0.008) blood pressure levels independent of differences in age, sex and known hypertension. There was a corresponding difference in BMI, being greater in subjects with than in those without retinopathy (32.4 vs. 29.2 kg/m2, p = 0.013). There were no associations between levels of fasting blood glucose or haemoglobin A1c, on the one hand, and retinopathy, on the other.<br/><br>
<br/><br>
Conclusion: Retinopathy may be present even before type 2 diabetes is manifest. It is associated with higher blood pressure levels and higher BMI values, that is, with predominant features of the metabolic syndrome.},
  author       = {Tyrberg, Maria and Melander, Arne and Lövestam Adrian, Monica and Lindblad, Ulf},
  issn         = {1462-8902},
  keyword      = {sulphonylurea,retinopathy,impaired fasting glucose,clinical trial,hypertension},
  language     = {eng},
  number       = {8},
  pages        = {646--651},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetes, Obesity and Metabolism},
  title        = {Retinopathy in subjects with impaired fasting glucose The NANSY – Eye Study, Baseline report},
  url          = {http://dx.doi.org/10.1111/j.1463-1326.2007.00759.x},
  volume       = {10},
  year         = {2008},
}