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Transthyretin in cerebrospinal fluid from suicide attempters.

Schultz, Kristofer LU ; Träskman Bendz, Lil LU and Petersén, Åsa LU (2008) In Journal of Affective Disorders 109(1-2). p.205-208
Abstract
BACKGROUND: Earlier studies have found that transthyretin (TTR) is reduced in cerebrospinal fluid (CSF) from patients with major depressive disorder and that levels correlate negatively with suicidal ideation. The purpose of this study was to examine CSF-TTR in a cohort of suicide attempters with different psychiatric diagnoses and to further assess the relationship between CSF-TTR and suicidal behaviour as well as psychiatric symptoms. METHODS: TTR was measured using enzyme-enhanced Mancini. Diagnostics were performed with the Diagnostic and Statistical Manual of Mental Disorders. Psychiatric symptoms and suicidal behaviour were rated using the Comprehensive Psychopathological Rating Scale (CPRS), the Suicide Assessment Scale and the... (More)
BACKGROUND: Earlier studies have found that transthyretin (TTR) is reduced in cerebrospinal fluid (CSF) from patients with major depressive disorder and that levels correlate negatively with suicidal ideation. The purpose of this study was to examine CSF-TTR in a cohort of suicide attempters with different psychiatric diagnoses and to further assess the relationship between CSF-TTR and suicidal behaviour as well as psychiatric symptoms. METHODS: TTR was measured using enzyme-enhanced Mancini. Diagnostics were performed with the Diagnostic and Statistical Manual of Mental Disorders. Psychiatric symptoms and suicidal behaviour were rated using the Comprehensive Psychopathological Rating Scale (CPRS), the Suicide Assessment Scale and the Suicidal Intent Scale. RESULTS: We found no significant difference in CSF-TTR levels between groups of different psychiatric diagnoses and controls. CSF-TTR correlated negatively to the CPRS item 17, "failing memory". No significant correlations between CSF-TTR and suicidal behaviour or suicide intent were found. LIMITATIONS: Correlation analysis is an indirect method of investigation and does not demonstrate causal relationships. CONCLUSIONS: We conclude that CSF-TTR is unlikely to be relevant for suicidal behaviour and that further studies in non-suicidal psychiatric patients are needed before a role of CSF-TTR in depression can be established. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Unipolar depression, Dysthymia, Transthyretin
in
Journal of Affective Disorders
volume
109
issue
1-2
pages
205 - 208
publisher
Elsevier
external identifiers
  • scopus:43949108254
  • wos:000256987300025
  • pmid:18166229
ISSN
1573-2517
DOI
10.1016/j.jad.2007.11.007
language
English
LU publication?
yes
id
e22c6fcb-5bdb-4c4b-8e28-9641a425a766 (old id 1140149)
date added to LUP
2008-02-13 15:08:55
date last changed
2017-01-01 04:57:54
@article{e22c6fcb-5bdb-4c4b-8e28-9641a425a766,
  abstract     = {BACKGROUND: Earlier studies have found that transthyretin (TTR) is reduced in cerebrospinal fluid (CSF) from patients with major depressive disorder and that levels correlate negatively with suicidal ideation. The purpose of this study was to examine CSF-TTR in a cohort of suicide attempters with different psychiatric diagnoses and to further assess the relationship between CSF-TTR and suicidal behaviour as well as psychiatric symptoms. METHODS: TTR was measured using enzyme-enhanced Mancini. Diagnostics were performed with the Diagnostic and Statistical Manual of Mental Disorders. Psychiatric symptoms and suicidal behaviour were rated using the Comprehensive Psychopathological Rating Scale (CPRS), the Suicide Assessment Scale and the Suicidal Intent Scale. RESULTS: We found no significant difference in CSF-TTR levels between groups of different psychiatric diagnoses and controls. CSF-TTR correlated negatively to the CPRS item 17, "failing memory". No significant correlations between CSF-TTR and suicidal behaviour or suicide intent were found. LIMITATIONS: Correlation analysis is an indirect method of investigation and does not demonstrate causal relationships. CONCLUSIONS: We conclude that CSF-TTR is unlikely to be relevant for suicidal behaviour and that further studies in non-suicidal psychiatric patients are needed before a role of CSF-TTR in depression can be established.},
  author       = {Schultz, Kristofer and Träskman Bendz, Lil and Petersén, Åsa},
  issn         = {1573-2517},
  keyword      = {Unipolar depression,Dysthymia,Transthyretin},
  language     = {eng},
  number       = {1-2},
  pages        = {205--208},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {Transthyretin in cerebrospinal fluid from suicide attempters.},
  url          = {http://dx.doi.org/10.1016/j.jad.2007.11.007},
  volume       = {109},
  year         = {2008},
}