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Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper

Kloppenburg, Margreet; Stamm, Tanja; Watt, Iain; Kainberger, Franz; Cawston, Tim E; Birrell, Fraser N; Petersson, Ingemar LU ; Saxne, Tore LU ; Kvien, Tore K and Slatkowsky-Christensen, Barbara, et al. (2007) In Annals of the Rheumatic Diseases 66(9). p.1157-1161
Abstract
BACKGROUND: Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of addressing key issues and facilitating research into hand osteoarthritis. OBJECTIVE: To review and discuss current knowledge on hand osteoarthritis with regard to aetiopathogenesis, diagnostic criteria, biomarkers and clinical outcome measures. METHODS: Recommendations were made based on a literature review. RESULTS: Outcomes of hand osteoarthritis should be explored, including patient perspective on the separate components... (More)
BACKGROUND: Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of addressing key issues and facilitating research into hand osteoarthritis. OBJECTIVE: To review and discuss current knowledge on hand osteoarthritis with regard to aetiopathogenesis, diagnostic criteria, biomarkers and clinical outcome measures. METHODS: Recommendations were made based on a literature review. RESULTS: Outcomes of hand osteoarthritis should be explored, including patient perspective on the separate components of disease activity, damage and functioning. All imaging techniques should be cross-validated for hand osteoarthritis with clinical status, including disease activity, function and performance, biomarkers and long-term outcome. New imaging modalities are available and need scoring systems and validation. The role of biomarkers in hand osteoarthritis has to be defined. CONCLUSION: Future research in hand osteoarthritis is warranted. (Less)
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Contribution to journal
publication status
published
subject
keywords
osteoarthritis, hand, outcome measures, biomarkers, imaging
in
Annals of the Rheumatic Diseases
volume
66
issue
9
pages
1157 - 1161
publisher
British Medical Association
external identifiers
  • pmid:17360780
  • scopus:34548162067
ISSN
1468-2060
DOI
10.1136/ard.2007.070813
language
English
LU publication?
yes
id
a8953b1a-2ba4-484b-93bf-09c2ec1cca5e (old id 1140203)
date added to LUP
2008-08-21 14:35:07
date last changed
2017-11-19 04:03:33
@article{a8953b1a-2ba4-484b-93bf-09c2ec1cca5e,
  abstract     = {BACKGROUND: Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of addressing key issues and facilitating research into hand osteoarthritis. OBJECTIVE: To review and discuss current knowledge on hand osteoarthritis with regard to aetiopathogenesis, diagnostic criteria, biomarkers and clinical outcome measures. METHODS: Recommendations were made based on a literature review. RESULTS: Outcomes of hand osteoarthritis should be explored, including patient perspective on the separate components of disease activity, damage and functioning. All imaging techniques should be cross-validated for hand osteoarthritis with clinical status, including disease activity, function and performance, biomarkers and long-term outcome. New imaging modalities are available and need scoring systems and validation. The role of biomarkers in hand osteoarthritis has to be defined. CONCLUSION: Future research in hand osteoarthritis is warranted.},
  author       = {Kloppenburg, Margreet and Stamm, Tanja and Watt, Iain and Kainberger, Franz and Cawston, Tim E and Birrell, Fraser N and Petersson, Ingemar and Saxne, Tore and Kvien, Tore K and Slatkowsky-Christensen, Barbara and Dougados, Maxime and Gossec, Laure and Breedveld, Ferdinand C and Smolen, Josef S},
  issn         = {1468-2060},
  keyword      = {osteoarthritis,hand,outcome measures,biomarkers,imaging},
  language     = {eng},
  number       = {9},
  pages        = {1157--1161},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper},
  url          = {http://dx.doi.org/10.1136/ard.2007.070813},
  volume       = {66},
  year         = {2007},
}