Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
(2007) In Breast Cancer Research and Treatment 105(2). p.221-228- Abstract
- An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth... (More)
- An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth in the cases and controls (24.9 years vs. 24.8 years; P = 0.81, respectively). Compared to women whose first child was born at or before 18 years of age, a later age at first full-term birth did not influence the risk of developing breast cancer (OR = 1.00 per year; 95% CI 0.98–1.03; P-trend = 0.67). Stratification by mutation status did not affect the results. These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA mutation carriers. Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective. (Less)
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https://lup.lub.lu.se/record/1140433
- author
- Kotsopoulos, J
; Lubinski, J
; Lynch, HT
; Klijn J, Ghadirian, P
; Neuhausen, SL
; Kim-Sing, C
; Foulkes, WD
; Moller, P
; Isaacs, C
; Domchek, S
; Randall, S
; Offit, K
; Tung, N
; Ainsworth, P
; Gershoni-Baruch, R
; Eisen, A
; Daly, Mark
LU
; Karlan, B
; Saal, HM
; Couch, F
; Pasini, Barbara
and Olsson, Håkan
LU
(Less) - author collaboration
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Case–control study, Breast cancer, BRCA2, Age at first birth, BRCA1
- in
- Breast Cancer Research and Treatment
- volume
- 105
- issue
- 2
- pages
- 221 - 228
- publisher
- Springer
- external identifiers
-
- scopus:34548436454
- ISSN
- 1573-7217
- DOI
- 10.1007/s10549-006-9441-3
- language
- English
- LU publication?
- yes
- id
- ed3d7690-8fe7-4ecd-80cc-d62014735b5a (old id 1140433)
- date added to LUP
- 2016-04-04 14:33:05
- date last changed
- 2024-04-18 20:08:39
@article{ed3d7690-8fe7-4ecd-80cc-d62014735b5a,
abstract = {{An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth in the cases and controls (24.9 years vs. 24.8 years; P = 0.81, respectively). Compared to women whose first child was born at or before 18 years of age, a later age at first full-term birth did not influence the risk of developing breast cancer (OR = 1.00 per year; 95% CI 0.98–1.03; P-trend = 0.67). Stratification by mutation status did not affect the results. These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA mutation carriers. Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective.}},
author = {{Kotsopoulos, J and Lubinski, J and Lynch, HT and Klijn J, Ghadirian, P and Neuhausen, SL and Kim-Sing, C and Foulkes, WD and Moller, P and Isaacs, C and Domchek, S and Randall, S and Offit, K and Tung, N and Ainsworth, P and Gershoni-Baruch, R and Eisen, A and Daly, Mark and Karlan, B and Saal, HM and Couch, F and Pasini, Barbara and Olsson, Håkan}},
issn = {{1573-7217}},
keywords = {{Case–control study; Breast cancer; BRCA2; Age at first birth; BRCA1}},
language = {{eng}},
number = {{2}},
pages = {{221--228}},
publisher = {{Springer}},
series = {{Breast Cancer Research and Treatment}},
title = {{Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.}},
url = {{http://dx.doi.org/10.1007/s10549-006-9441-3}},
doi = {{10.1007/s10549-006-9441-3}},
volume = {{105}},
year = {{2007}},
}