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Cell-based therapies for acute liver failure: human tissue engineering, pure cell implantation and stem cell application

Andersson, Roland LU and Wang, Xiangdong LU (2007) In Journal of Organ Dysfuntion 3(4). p.194-203
Abstract
Improving the survival rate and quality of life of patients with acute and chronic hepatic dysfunction still represents a challenge. Cell-based therapeutic hepatocyte transplantation has great potential to serve as a temporary support and “bridge” prior to a donor organ becoming available, or even as therapy for replacing a compromised liver. In this review we describe potential applications of human tissue engineering, compare therapeutic effects of transplanted hepatocytes, with or without tissue engineering and highlight the exciting progress of stem cell transplantation in hepatic dysfunction. Hepatocytes can be transplanted in the form of pure cells or as cells engineered with devices (with or without pretreatment with growth... (More)
Improving the survival rate and quality of life of patients with acute and chronic hepatic dysfunction still represents a challenge. Cell-based therapeutic hepatocyte transplantation has great potential to serve as a temporary support and “bridge” prior to a donor organ becoming available, or even as therapy for replacing a compromised liver. In this review we describe potential applications of human tissue engineering, compare therapeutic effects of transplanted hepatocytes, with or without tissue engineering and highlight the exciting progress of stem cell transplantation in hepatic dysfunction. Hepatocytes can be transplanted in the form of pure cells or as cells engineered with devices (with or without pretreatment with growth factors), freshly isolated or preserved cells or adult matured or stem cells. The efficacy of different forms of cell-based therapy may be associated with the severity and duration of the disease and with the therapeutic strategy used to treat it. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Organ Dysfuntion
volume
3
issue
4
pages
194 - 203
publisher
Informa Healthcare
external identifiers
  • scopus:35848934376
ISSN
1747-1060
DOI
10.1080/17471060600804130
language
English
LU publication?
yes
id
33eb8aa4-0592-4421-adc7-d92d9a9cec27 (old id 1142993)
date added to LUP
2008-07-31 13:29:58
date last changed
2017-01-01 04:52:57
@article{33eb8aa4-0592-4421-adc7-d92d9a9cec27,
  abstract     = {Improving the survival rate and quality of life of patients with acute and chronic hepatic dysfunction still represents a challenge. Cell-based therapeutic hepatocyte transplantation has great potential to serve as a temporary support and “bridge” prior to a donor organ becoming available, or even as therapy for replacing a compromised liver. In this review we describe potential applications of human tissue engineering, compare therapeutic effects of transplanted hepatocytes, with or without tissue engineering and highlight the exciting progress of stem cell transplantation in hepatic dysfunction. Hepatocytes can be transplanted in the form of pure cells or as cells engineered with devices (with or without pretreatment with growth factors), freshly isolated or preserved cells or adult matured or stem cells. The efficacy of different forms of cell-based therapy may be associated with the severity and duration of the disease and with the therapeutic strategy used to treat it.},
  author       = {Andersson, Roland and Wang, Xiangdong},
  issn         = {1747-1060},
  language     = {eng},
  number       = {4},
  pages        = {194--203},
  publisher    = {Informa Healthcare},
  series       = {Journal of Organ Dysfuntion},
  title        = {Cell-based therapies for acute liver failure: human tissue engineering, pure cell implantation and stem cell application},
  url          = {http://dx.doi.org/10.1080/17471060600804130},
  volume       = {3},
  year         = {2007},
}