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Maternal use of loperamide in early pregnancy and delivery outcome.

Källén, Bengt LU ; Nilsson, Emma and Otterblad Olausson, Petra (2008) In Acta Pædiatrica 97(5). p.541-545
Abstract
Aim: To study delivery outcome including presence of infant congenital malformations after maternal use of loperamide in early pregnancy. Methods: Using the Swedish Medical Birth Register, women reporting the use of loperamide in early pregnancy were compared with other women for the period July 1, 1995-2004. Odds ratios (OR) or risk ratios (RR) were estimated after adjustment for some variables, which were associated with the use of loperamide (year of delivery, maternal age, parity, smoking, number of previous miscarriages). Results: Characteristics of women using loperamide in early pregnancy were identified. An analysis of concomitant drug use indicated that only few of the women had inflammatory bowel disease. The risk of any... (More)
Aim: To study delivery outcome including presence of infant congenital malformations after maternal use of loperamide in early pregnancy. Methods: Using the Swedish Medical Birth Register, women reporting the use of loperamide in early pregnancy were compared with other women for the period July 1, 1995-2004. Odds ratios (OR) or risk ratios (RR) were estimated after adjustment for some variables, which were associated with the use of loperamide (year of delivery, maternal age, parity, smoking, number of previous miscarriages). Results: Characteristics of women using loperamide in early pregnancy were identified. An analysis of concomitant drug use indicated that only few of the women had inflammatory bowel disease. The risk of any congenital malformation was increased (OR = 1.43, 95% CI 1.04-1.96), based on 43 cases, but no major contributing type could be identified. The risk of hypospadias was significantly increased (RR = 3.2, 95% CI 1.3-6.6), based on seven cases. A statistically significant increase was seen also for placenta previa, large for gestational age and caesarean section. Conclusion: Maternal use of loperamide in early pregnancy may be associated with a moderate risk increase for a malformation in the infant. The finding should be evaluated from other large studies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pædiatrica
volume
97
issue
5
pages
541 - 545
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000254988600007
  • pmid:18394096
  • scopus:41749113848
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2008.00718.x
language
English
LU publication?
yes
id
6ac5cfab-4adc-4dd3-b3ac-1f206a51c40b (old id 1147663)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18394096?dopt=Abstract
date added to LUP
2008-05-08 10:42:14
date last changed
2017-02-22 10:46:52
@article{6ac5cfab-4adc-4dd3-b3ac-1f206a51c40b,
  abstract     = {Aim: To study delivery outcome including presence of infant congenital malformations after maternal use of loperamide in early pregnancy. Methods: Using the Swedish Medical Birth Register, women reporting the use of loperamide in early pregnancy were compared with other women for the period July 1, 1995-2004. Odds ratios (OR) or risk ratios (RR) were estimated after adjustment for some variables, which were associated with the use of loperamide (year of delivery, maternal age, parity, smoking, number of previous miscarriages). Results: Characteristics of women using loperamide in early pregnancy were identified. An analysis of concomitant drug use indicated that only few of the women had inflammatory bowel disease. The risk of any congenital malformation was increased (OR = 1.43, 95% CI 1.04-1.96), based on 43 cases, but no major contributing type could be identified. The risk of hypospadias was significantly increased (RR = 3.2, 95% CI 1.3-6.6), based on seven cases. A statistically significant increase was seen also for placenta previa, large for gestational age and caesarean section. Conclusion: Maternal use of loperamide in early pregnancy may be associated with a moderate risk increase for a malformation in the infant. The finding should be evaluated from other large studies.},
  author       = {Källén, Bengt and Nilsson, Emma and Otterblad Olausson, Petra},
  issn         = {1651-2227},
  language     = {eng},
  number       = {5},
  pages        = {541--545},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Maternal use of loperamide in early pregnancy and delivery outcome.},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2008.00718.x},
  volume       = {97},
  year         = {2008},
}