Advanced

Corneal epithelial keratitis in herpes zoster ophthalmicus: "delayed" and "sine herpete". A non-contact photomicrographic in vivo study in the human cornea.

Tabery, Helena LU (2002) In European Journal of Ophthalmology 12(4). p.267-275
Abstract
PURPOSE. To investigate the origin of corneal epithelial keratitis occurring without accompanying herpes zoster ophthalmicus (HZO) cutaneous rash. METHODS. Corneal epithelial lesions in seven patients (four with a history of classical HZO with cutaneous rash, one of herpes zoster oticus, and two with no history of herpes zoster, were examined with the slit lamp and photographed by non-contact in vivo photomicrography. The findings were compared with lesions in classical acute HZO. Polymerase chain reaction (PCR) was done in three patients. RESULTS. Slit lamp appearance, morphology at higher magnification, and kinetics of the lesions were indistinguishable from classical acute HZO. PCR was positive for varicella-zoster virus DNA in all... (More)
PURPOSE. To investigate the origin of corneal epithelial keratitis occurring without accompanying herpes zoster ophthalmicus (HZO) cutaneous rash. METHODS. Corneal epithelial lesions in seven patients (four with a history of classical HZO with cutaneous rash, one of herpes zoster oticus, and two with no history of herpes zoster, were examined with the slit lamp and photographed by non-contact in vivo photomicrography. The findings were compared with lesions in classical acute HZO. Polymerase chain reaction (PCR) was done in three patients. RESULTS. Slit lamp appearance, morphology at higher magnification, and kinetics of the lesions were indistinguishable from classical acute HZO. PCR was positive for varicella-zoster virus DNA in all three samples. CONCLUSIONS. The findings strongly suggest that HZO typical corneal epithelial lesions occurring in the absence of cutaneous rash are in fact recurrent episodes of virus shedding. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Corneal: virology, Herpesvirus 3, Human, Keratitis, Human: genetics, Human: isolation & purification, Herpetic: pathology, Zoster Sine Herpete: virology, Recurrence, Support, Non-U.S. Gov't, Virus Shedding: physiology, Zoster Sine Herpete: pathology, Polymerase Chain Reaction, Middle Age, Male, Herpetic: virology, Female, Herpes Zoster Ophthalmicus: pathology, Herpes Zoster Ophthalmicus: virology, Herpes Zoster Oticus: pathology, Herpes Zoster Oticus: virology, Corneal: pathology, Epithelium, Viral: analysis, Aged, 80 and over, Case Report, Comparative Study, DNA
in
European Journal of Ophthalmology
volume
12
issue
4
pages
267 - 275
publisher
Wichtig Editore
external identifiers
  • wos:000177771800003
  • scopus:0036657382
ISSN
1120-6721
language
English
LU publication?
yes
id
1e3d1ea1-ba9e-4256-9e59-b4048b8834e5 (old id 114893)
alternative location
http://www.eur-j-ophthalmol.com/ejo/index.asp?a=abstract&id=48812DD6-B1B4-11D6-9FAE-006097F
date added to LUP
2007-07-30 11:12:35
date last changed
2017-01-01 04:37:10
@article{1e3d1ea1-ba9e-4256-9e59-b4048b8834e5,
  abstract     = {PURPOSE. To investigate the origin of corneal epithelial keratitis occurring without accompanying herpes zoster ophthalmicus (HZO) cutaneous rash. METHODS. Corneal epithelial lesions in seven patients (four with a history of classical HZO with cutaneous rash, one of herpes zoster oticus, and two with no history of herpes zoster, were examined with the slit lamp and photographed by non-contact in vivo photomicrography. The findings were compared with lesions in classical acute HZO. Polymerase chain reaction (PCR) was done in three patients. RESULTS. Slit lamp appearance, morphology at higher magnification, and kinetics of the lesions were indistinguishable from classical acute HZO. PCR was positive for varicella-zoster virus DNA in all three samples. CONCLUSIONS. The findings strongly suggest that HZO typical corneal epithelial lesions occurring in the absence of cutaneous rash are in fact recurrent episodes of virus shedding.},
  author       = {Tabery, Helena},
  issn         = {1120-6721},
  keyword      = {Corneal: virology,Herpesvirus 3,Human,Keratitis,Human: genetics,Human: isolation & purification,Herpetic: pathology,Zoster Sine Herpete: virology,Recurrence,Support,Non-U.S. Gov't,Virus Shedding: physiology,Zoster Sine Herpete: pathology,Polymerase Chain Reaction,Middle Age,Male,Herpetic: virology,Female,Herpes Zoster Ophthalmicus: pathology,Herpes Zoster Ophthalmicus: virology,Herpes Zoster Oticus: pathology,Herpes Zoster Oticus: virology,Corneal: pathology,Epithelium,Viral: analysis,Aged,80 and over,Case Report,Comparative Study,DNA},
  language     = {eng},
  number       = {4},
  pages        = {267--275},
  publisher    = {Wichtig Editore},
  series       = {European Journal of Ophthalmology},
  title        = {Corneal epithelial keratitis in herpes zoster ophthalmicus: "delayed" and "sine herpete". A non-contact photomicrographic in vivo study in the human cornea.},
  volume       = {12},
  year         = {2002},
}