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Vacuum-assisted closure therapy for deep sternal wound infections: the impact of learning curve on survival and predictors for late mortality.

Sjögren, Johan LU ; Mokhtari, Arash LU ; Gustafsson, Ronny LU ; Malmsjö, Malin LU ; Nilsson, Johan and Ingemansson, Richard LU (2008) In International Wound Journal 5(2). p.216-223
Abstract
The aim of this study was to evaluate the possible learning curve effects on survival during the introduction of vacuum-assisted closure (VAC) therapy in patients with deep sternal wound infection (DSWI). Furthermore, predictors of late mortality were analysed and causes of late death were examined. Fifty-three patients (early Group, n = 26, January 1999 to July 2001 versus late group, n = 27, August 2001 to March 2003) were all treated with VAC for DSWI. A follow-up was carried out in September 2006. Multivariate analyses were used to evaluate the predictors of late mortality. The 90-day mortality was 0% in both groups. The survival rates at 5 years were 69.2 +/- 9.1% (early group) versus 58.5 +/- 11.7% (late group), P = ns (non... (More)
The aim of this study was to evaluate the possible learning curve effects on survival during the introduction of vacuum-assisted closure (VAC) therapy in patients with deep sternal wound infection (DSWI). Furthermore, predictors of late mortality were analysed and causes of late death were examined. Fifty-three patients (early Group, n = 26, January 1999 to July 2001 versus late group, n = 27, August 2001 to March 2003) were all treated with VAC for DSWI. A follow-up was carried out in September 2006. Multivariate analyses were used to evaluate the predictors of late mortality. The 90-day mortality was 0% in both groups. The survival rates at 5 years were 69.2 +/- 9.1% (early group) versus 58.5 +/- 11.7% (late group), P = ns (non significant). The time interval from cardiac surgery to diagnosis of DSWI and prolonged VAC therapy were identified as independent predictors of late mortality. Our concept for VAC therapy in DSWI seems to be readily introduced in clinical practice. There was no difference in survival between our initial cases and later cases. Late diagnosis and prolonged wound therapy were identified as predictors for late mortality. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Wound Journal
volume
5
issue
2
pages
216 - 223
publisher
Wiley-Blackwell
external identifiers
  • wos:000207843500010
  • pmid:18494627
  • scopus:44349088954
ISSN
1742-481X
DOI
10.1111/j.1742-481X.2007.00371.x
language
English
LU publication?
yes
id
9cba05c4-e333-47d6-82fa-c4129e04b71c (old id 1153905)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18494627?dopt=Abstract
date added to LUP
2008-06-04 10:22:17
date last changed
2017-01-01 07:39:09
@article{9cba05c4-e333-47d6-82fa-c4129e04b71c,
  abstract     = {The aim of this study was to evaluate the possible learning curve effects on survival during the introduction of vacuum-assisted closure (VAC) therapy in patients with deep sternal wound infection (DSWI). Furthermore, predictors of late mortality were analysed and causes of late death were examined. Fifty-three patients (early Group, n = 26, January 1999 to July 2001 versus late group, n = 27, August 2001 to March 2003) were all treated with VAC for DSWI. A follow-up was carried out in September 2006. Multivariate analyses were used to evaluate the predictors of late mortality. The 90-day mortality was 0% in both groups. The survival rates at 5 years were 69.2 +/- 9.1% (early group) versus 58.5 +/- 11.7% (late group), P = ns (non significant). The time interval from cardiac surgery to diagnosis of DSWI and prolonged VAC therapy were identified as independent predictors of late mortality. Our concept for VAC therapy in DSWI seems to be readily introduced in clinical practice. There was no difference in survival between our initial cases and later cases. Late diagnosis and prolonged wound therapy were identified as predictors for late mortality.},
  author       = {Sjögren, Johan and Mokhtari, Arash and Gustafsson, Ronny and Malmsjö, Malin and Nilsson, Johan and Ingemansson, Richard},
  issn         = {1742-481X},
  language     = {eng},
  number       = {2},
  pages        = {216--223},
  publisher    = {Wiley-Blackwell},
  series       = {International Wound Journal},
  title        = {Vacuum-assisted closure therapy for deep sternal wound infections: the impact of learning curve on survival and predictors for late mortality.},
  url          = {http://dx.doi.org/10.1111/j.1742-481X.2007.00371.x},
  volume       = {5},
  year         = {2008},
}