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Hormone-sensitive lipase is necessary for normal mobilization of lipids during sub-maximal exercise.

Fernandez, Celine LU ; Hansson, Ola LU ; Nevsten, Pernilla LU ; Holm, Cecilia LU and Klint, Cecilia LU (2008) In American Journal of Physiology: Endocrinology and Metabolism 295. p.179-186
Abstract
For the working muscle there are a number of fuels available for oxidative metabolism, including glycogen, glucose and non-esterified fatty acids. Non-esterified fatty acids originate from lipolysis in white adipose tissue, from hydrolysis of VLDL-triglycerides or from hydrolysis of intramyocellular triglyceride stores. A key enzyme in the mobilization of fatty acids from intracellular lipid stores is hormone-sensitive lipase (HSL). The aim of the present study was to investigate the metabolic response of HSL-null mice challenged with exercise or fasting and to examine if other lipases are able to fully compensate for the lack of HSL. The results showed that HSL-null mice have reduced capacity to perform aerobic exercise. The liver... (More)
For the working muscle there are a number of fuels available for oxidative metabolism, including glycogen, glucose and non-esterified fatty acids. Non-esterified fatty acids originate from lipolysis in white adipose tissue, from hydrolysis of VLDL-triglycerides or from hydrolysis of intramyocellular triglyceride stores. A key enzyme in the mobilization of fatty acids from intracellular lipid stores is hormone-sensitive lipase (HSL). The aim of the present study was to investigate the metabolic response of HSL-null mice challenged with exercise or fasting and to examine if other lipases are able to fully compensate for the lack of HSL. The results showed that HSL-null mice have reduced capacity to perform aerobic exercise. The liver glycogen stores were more rapidly depleted in HSL-null mice during treadmill exercise and HSL-null mice had reduced plasma concentrations of both glycerol and non-esterified fatty acids after exercise and fasting, respectively. The data support the hypothesis that in the absence of HSL mice are not able to respond to an exercise challenge with increased mobilization of the lipid stores. Consequently, the impact of the lipid sparing effect on liver glycogen will be reduced in the HSL-null mice, resulting in faster depletion of this energy source, contributing to the decreased endurance during sub-maximal exercise. Key words: Treadmill exercise, lipid metabolism, glycogen, skeletal muscle, liver. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Physiology: Endocrinology and Metabolism
volume
295
pages
179 - 186
publisher
American Physiological Society
external identifiers
  • wos:000258142400023
  • pmid:18492774
  • scopus:50349095537
ISSN
1522-1555
DOI
10.1152/ajpendo.00282.2007
language
English
LU publication?
yes
id
762c88aa-bbdf-4863-be8e-9e8a2eccdf0b (old id 1153932)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18492774?dopt=Abstract
date added to LUP
2008-06-04 10:32:36
date last changed
2017-06-18 04:42:03
@article{762c88aa-bbdf-4863-be8e-9e8a2eccdf0b,
  abstract     = {For the working muscle there are a number of fuels available for oxidative metabolism, including glycogen, glucose and non-esterified fatty acids. Non-esterified fatty acids originate from lipolysis in white adipose tissue, from hydrolysis of VLDL-triglycerides or from hydrolysis of intramyocellular triglyceride stores. A key enzyme in the mobilization of fatty acids from intracellular lipid stores is hormone-sensitive lipase (HSL). The aim of the present study was to investigate the metabolic response of HSL-null mice challenged with exercise or fasting and to examine if other lipases are able to fully compensate for the lack of HSL. The results showed that HSL-null mice have reduced capacity to perform aerobic exercise. The liver glycogen stores were more rapidly depleted in HSL-null mice during treadmill exercise and HSL-null mice had reduced plasma concentrations of both glycerol and non-esterified fatty acids after exercise and fasting, respectively. The data support the hypothesis that in the absence of HSL mice are not able to respond to an exercise challenge with increased mobilization of the lipid stores. Consequently, the impact of the lipid sparing effect on liver glycogen will be reduced in the HSL-null mice, resulting in faster depletion of this energy source, contributing to the decreased endurance during sub-maximal exercise. Key words: Treadmill exercise, lipid metabolism, glycogen, skeletal muscle, liver.},
  author       = {Fernandez, Celine and Hansson, Ola and Nevsten, Pernilla and Holm, Cecilia and Klint, Cecilia},
  issn         = {1522-1555},
  language     = {eng},
  pages        = {179--186},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Endocrinology and Metabolism},
  title        = {Hormone-sensitive lipase is necessary for normal mobilization of lipids during sub-maximal exercise.},
  url          = {http://dx.doi.org/10.1152/ajpendo.00282.2007},
  volume       = {295},
  year         = {2008},
}