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Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2.

Uddman, Rolf LU ; Tajti, J ; Hou, M ; Sundler, Frank LU and Edvinsson, Lars LU (2002) In Cephalalgia 22(2). p.112-116
Abstract
In migraine and other primary headaches there is a strong vascular component. Besides the trigeminovascular components some of the associated symptoms point to the involvement of brain stem regions. The central limb of the trigeminal vascular pathway is its projection to the trigeminal nucleus caudalis (TNC) and to the C1-C2 levels of the spinal cord. The aim of the present study was to demonstrate the occurrence of some neurotransmitters in these regions in man. In both the TNC and in the Rexed's laminae I and II of the dorsal horns at the C1 and C2 levels there were numerous substance P immunoreactive fibres. Fibres containing calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) were... (More)
In migraine and other primary headaches there is a strong vascular component. Besides the trigeminovascular components some of the associated symptoms point to the involvement of brain stem regions. The central limb of the trigeminal vascular pathway is its projection to the trigeminal nucleus caudalis (TNC) and to the C1-C2 levels of the spinal cord. The aim of the present study was to demonstrate the occurrence of some neurotransmitters in these regions in man. In both the TNC and in the Rexed's laminae I and II of the dorsal horns at the C1 and C2 levels there were numerous substance P immunoreactive fibres. Fibres containing calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) were moderately dense in number. Fibres containing vasoactive intestinal peptide (VIP) or nitric oxide synthase (NOS) were not seen in the TNC or at the C1 and C2 levels of the spinal cord. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Vasoactive Intestinal Peptide: metabolism, Adult, Aged, Calcitonin Gene-Related Peptide: metabolism, Cervical Vertebrae, Non-U.S. Gov't, Trigeminal Caudal Nucleus: metabolism, Female, Human, Immunohistochemistry, Male, Middle Age, Neuropeptides: metabolism, Spinal Cord: metabolism, Substance P: metabolism, Support
in
Cephalalgia
volume
22
issue
2
pages
112 - 116
publisher
Wiley-Blackwell
external identifiers
  • wos:000175184400005
  • pmid:11972578
  • scopus:0036260865
ISSN
0333-1024
DOI
10.1046/j.1468-2982.2002.00324.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Oto-Rhino-Laryngology (013243500), Medicine (Lund) (013230025), Neuroendocrine Cell Biology (013212008), Clinical and Experimental Allergy Research (013243510)
id
4acbb892-c1b7-4a53-b6f0-75a042f734ae (old id 115413)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11972578&ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
date added to LUP
2016-04-01 15:54:10
date last changed
2024-02-26 07:17:11
@article{4acbb892-c1b7-4a53-b6f0-75a042f734ae,
  abstract     = {{In migraine and other primary headaches there is a strong vascular component. Besides the trigeminovascular components some of the associated symptoms point to the involvement of brain stem regions. The central limb of the trigeminal vascular pathway is its projection to the trigeminal nucleus caudalis (TNC) and to the C1-C2 levels of the spinal cord. The aim of the present study was to demonstrate the occurrence of some neurotransmitters in these regions in man. In both the TNC and in the Rexed's laminae I and II of the dorsal horns at the C1 and C2 levels there were numerous substance P immunoreactive fibres. Fibres containing calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) were moderately dense in number. Fibres containing vasoactive intestinal peptide (VIP) or nitric oxide synthase (NOS) were not seen in the TNC or at the C1 and C2 levels of the spinal cord.}},
  author       = {{Uddman, Rolf and Tajti, J and Hou, M and Sundler, Frank and Edvinsson, Lars}},
  issn         = {{0333-1024}},
  keywords     = {{Vasoactive Intestinal Peptide: metabolism; Adult; Aged; Calcitonin Gene-Related Peptide: metabolism; Cervical Vertebrae; Non-U.S. Gov't; Trigeminal Caudal Nucleus: metabolism; Female; Human; Immunohistochemistry; Male; Middle Age; Neuropeptides: metabolism; Spinal Cord: metabolism; Substance P: metabolism; Support}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{112--116}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cephalalgia}},
  title        = {{Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2.}},
  url          = {{https://lup.lub.lu.se/search/files/4507733/623800.pdf}},
  doi          = {{10.1046/j.1468-2982.2002.00324.x}},
  volume       = {{22}},
  year         = {{2002}},
}