Advanced

Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats.

Åkesson, Lina LU ; Gelling, R; Jensen, R; Ogimoto, K; Fuller, J; Pefley, R; Manavi, S; Lernmark, Åke LU and Schwartz, M (2008) In Experimental and Clinical Endocrinology & Diabetes 116. p.475-480
Abstract
AIM: The BB rat model of type 1 diabetes exhibits altered body weight gain and body temperature regulation prior to hyperglycemia onset, implying the existence of as yet unidentified biomarkers of autoimmune processes that destroy pancreatic beta cells. To investigate this hypothesis, we compared the metabolic profile of diabetes-resistant DR.lyp/+ rats and their diabetes-prone, congenic DR.lyp/lyp littermates in the days leading up to diabetes onset. METHODS: Except for the Gimap5 mutation on chromosome 4, congenic DR.lyp/lyp rats are genetically identical to DR.lyp/+ littermates. They invariably develop hyperglycemia at 46-81 days of age, whereas DR.lyp/+ rats do not develop diabetes. In addition to daily food intake and body weight,... (More)
AIM: The BB rat model of type 1 diabetes exhibits altered body weight gain and body temperature regulation prior to hyperglycemia onset, implying the existence of as yet unidentified biomarkers of autoimmune processes that destroy pancreatic beta cells. To investigate this hypothesis, we compared the metabolic profile of diabetes-resistant DR.lyp/+ rats and their diabetes-prone, congenic DR.lyp/lyp littermates in the days leading up to diabetes onset. METHODS: Except for the Gimap5 mutation on chromosome 4, congenic DR.lyp/lyp rats are genetically identical to DR.lyp/+ littermates. They invariably develop hyperglycemia at 46-81 days of age, whereas DR.lyp/+ rats do not develop diabetes. In addition to daily food intake and body weight, indirect calorimetry was performed continuously on male DR.lyp/lyp and DR.lyp/+ rats (n=6/group) for 6-18 days to measure locomotor activity, VO (2), VCO (2) and RQ. RESULTS: DR.lyp/lyp rats exhibited a progressive decrease of RQ compared to DR.lyp/+ rats 0.005+/-0.001 units/day (p<0.005). Limiting the analysis to the six days prior to diabetes onset revealed a larger decrease of 0.007+/-0.002 units/day (p<0.001) in DR.lyp/lyp animals, whereas RQ of the DR.lyp/+ rats remained unchanged. This metabolic change occurred prior to hyperglycemia onset and was not associated with changes of any other parameter. CONCLUSIONS: Diabetes onset in DR.lyp/lyp rats is heralded by a progressive shift towards lipid oxidation relative to carbohydrate metabolism. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental and Clinical Endocrinology & Diabetes
volume
116
pages
475 - 480
publisher
Georg Thieme Verlag
external identifiers
  • wos:000259927300004
  • pmid:18465680
  • scopus:54549102205
ISSN
1439-3646
DOI
10.1055/s-2008-1062713
language
English
LU publication?
yes
id
63dfba98-30ad-4deb-bf16-4cdd9ff6b484 (old id 1154415)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18465680?dopt=Abstract
date added to LUP
2008-06-03 11:14:36
date last changed
2017-02-26 04:22:07
@article{63dfba98-30ad-4deb-bf16-4cdd9ff6b484,
  abstract     = {AIM: The BB rat model of type 1 diabetes exhibits altered body weight gain and body temperature regulation prior to hyperglycemia onset, implying the existence of as yet unidentified biomarkers of autoimmune processes that destroy pancreatic beta cells. To investigate this hypothesis, we compared the metabolic profile of diabetes-resistant DR.lyp/+ rats and their diabetes-prone, congenic DR.lyp/lyp littermates in the days leading up to diabetes onset. METHODS: Except for the Gimap5 mutation on chromosome 4, congenic DR.lyp/lyp rats are genetically identical to DR.lyp/+ littermates. They invariably develop hyperglycemia at 46-81 days of age, whereas DR.lyp/+ rats do not develop diabetes. In addition to daily food intake and body weight, indirect calorimetry was performed continuously on male DR.lyp/lyp and DR.lyp/+ rats (n=6/group) for 6-18 days to measure locomotor activity, VO (2), VCO (2) and RQ. RESULTS: DR.lyp/lyp rats exhibited a progressive decrease of RQ compared to DR.lyp/+ rats 0.005+/-0.001 units/day (p&lt;0.005). Limiting the analysis to the six days prior to diabetes onset revealed a larger decrease of 0.007+/-0.002 units/day (p&lt;0.001) in DR.lyp/lyp animals, whereas RQ of the DR.lyp/+ rats remained unchanged. This metabolic change occurred prior to hyperglycemia onset and was not associated with changes of any other parameter. CONCLUSIONS: Diabetes onset in DR.lyp/lyp rats is heralded by a progressive shift towards lipid oxidation relative to carbohydrate metabolism.},
  author       = {Åkesson, Lina and Gelling, R and Jensen, R and Ogimoto, K and Fuller, J and Pefley, R and Manavi, S and Lernmark, Åke and Schwartz, M},
  issn         = {1439-3646},
  language     = {eng},
  pages        = {475--480},
  publisher    = {Georg Thieme Verlag},
  series       = {Experimental and Clinical Endocrinology & Diabetes},
  title        = {Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats.},
  url          = {http://dx.doi.org/10.1055/s-2008-1062713},
  volume       = {116},
  year         = {2008},
}