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Muscle Determinants of Bone Mass, Geometry and Strength in Prepubertal Girls.

Daly, Robin; Stenevi Lundgren, Susanna LU ; Lindén, Christian LU and Karlsson, Magnus LU (2008) In Medicine & Science in Sports & Exercise 40(6). p.1135-1141
Abstract
PURPOSE:: The aim of this study was to compare the relative contribution of peak muscle force (isokinetic peak torque) with surrogate estimates of muscle force, including leg lean tissue mass (LTM) and vertical jump height (VJH), on bone mass, geometry and strength in healthy prepubertal girls (n = 103). METHODS:: Total leg and FN BMC and leg LTM were measured by DXA; the hip strength analysis program was used to assess FN diameter, cross-sectional area (CSA) and section modulus (Z). Isokinetic peak torque of the knee extensors and flexors (60 degrees .s) were used as direct measures of peak muscle force. VJH was measured as an estimate of neuromuscular function. Total leg length or femoral length was used as a surrogate measure of moment... (More)
PURPOSE:: The aim of this study was to compare the relative contribution of peak muscle force (isokinetic peak torque) with surrogate estimates of muscle force, including leg lean tissue mass (LTM) and vertical jump height (VJH), on bone mass, geometry and strength in healthy prepubertal girls (n = 103). METHODS:: Total leg and FN BMC and leg LTM were measured by DXA; the hip strength analysis program was used to assess FN diameter, cross-sectional area (CSA) and section modulus (Z). Isokinetic peak torque of the knee extensors and flexors (60 degrees .s) were used as direct measures of peak muscle force. VJH was measured as an estimate of neuromuscular function. Total leg length or femoral length was used as a surrogate measure of moment arm length. RESULTS:: All estimates of muscle function, except VJH, were positively associated with leg BMC (r = 0.72 - 0.90) and FN BMC, geometry and strength (r = 0.35-0.65) (all, P < 0.001). Multiple linear regression analyses revealed that leg LTM and isokinetic peak torque were independently and equally predictive of leg BMC and FN BMC, bone geometry and strength, explaining 8 to 28% of the variance in each of the bone traits after accounting for moment arm length. When isokinetic peak torque was corrected for both leg LTM and moment arm length, it remained an independent predictor of BMC, CSA and Z, but only accounted for an additional 2 to 5% of the variance. CONCLUSION:: These data suggest that DXA-derived leg LTM can be used as a reasonable surrogate for isokinetic peak muscle forces when assessing bone strength in relation to muscular function in healthy pre-pubertal girls. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Medicine & Science in Sports & Exercise
volume
40
issue
6
pages
1135 - 1141
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000256157500020
  • pmid:18460991
  • scopus:54049122268
ISSN
1530-0315
DOI
10.1249/MSS.0b013e318169bb8d
language
English
LU publication?
yes
id
6aa2ec4f-97ae-46a5-bd20-69a34ea10ae3 (old id 1154513)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18460991?dopt=Abstract
date added to LUP
2008-06-02 13:47:19
date last changed
2017-07-30 04:52:18
@article{6aa2ec4f-97ae-46a5-bd20-69a34ea10ae3,
  abstract     = {PURPOSE:: The aim of this study was to compare the relative contribution of peak muscle force (isokinetic peak torque) with surrogate estimates of muscle force, including leg lean tissue mass (LTM) and vertical jump height (VJH), on bone mass, geometry and strength in healthy prepubertal girls (n = 103). METHODS:: Total leg and FN BMC and leg LTM were measured by DXA; the hip strength analysis program was used to assess FN diameter, cross-sectional area (CSA) and section modulus (Z). Isokinetic peak torque of the knee extensors and flexors (60 degrees .s) were used as direct measures of peak muscle force. VJH was measured as an estimate of neuromuscular function. Total leg length or femoral length was used as a surrogate measure of moment arm length. RESULTS:: All estimates of muscle function, except VJH, were positively associated with leg BMC (r = 0.72 - 0.90) and FN BMC, geometry and strength (r = 0.35-0.65) (all, P &lt; 0.001). Multiple linear regression analyses revealed that leg LTM and isokinetic peak torque were independently and equally predictive of leg BMC and FN BMC, bone geometry and strength, explaining 8 to 28% of the variance in each of the bone traits after accounting for moment arm length. When isokinetic peak torque was corrected for both leg LTM and moment arm length, it remained an independent predictor of BMC, CSA and Z, but only accounted for an additional 2 to 5% of the variance. CONCLUSION:: These data suggest that DXA-derived leg LTM can be used as a reasonable surrogate for isokinetic peak muscle forces when assessing bone strength in relation to muscular function in healthy pre-pubertal girls.},
  author       = {Daly, Robin and Stenevi Lundgren, Susanna and Lindén, Christian and Karlsson, Magnus},
  issn         = {1530-0315},
  language     = {eng},
  number       = {6},
  pages        = {1135--1141},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Medicine & Science in Sports & Exercise},
  title        = {Muscle Determinants of Bone Mass, Geometry and Strength in Prepubertal Girls.},
  url          = {http://dx.doi.org/10.1249/MSS.0b013e318169bb8d},
  volume       = {40},
  year         = {2008},
}