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Lower breast cancer survival in mothers of children with a malignancy: a national study.

Olsson, Håkan LU ; Magnusson, Susanne LU and Bladström, Anna LU (2008) In British Journal of Cancer 98(11). p.1876-1878
Abstract
As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (<or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer... (More)
As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (<or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li-Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
98
issue
11
pages
1876 - 1878
publisher
Nature Publishing Group
external identifiers
  • wos:000256308600026
  • pmid:18458676
  • scopus:44349107014
ISSN
1532-1827
DOI
10.1038/sj.bjc.6604350
language
English
LU publication?
yes
id
28ef7775-876d-42ad-973a-5ef7305c028f (old id 1154547)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18458676?dopt=Abstract
date added to LUP
2008-06-04 11:13:29
date last changed
2017-01-01 07:40:44
@article{28ef7775-876d-42ad-973a-5ef7305c028f,
  abstract     = {As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (&lt;or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P&lt;0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li-Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival.},
  author       = {Olsson, Håkan and Magnusson, Susanne and Bladström, Anna},
  issn         = {1532-1827},
  language     = {eng},
  number       = {11},
  pages        = {1876--1878},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Lower breast cancer survival in mothers of children with a malignancy: a national study.},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6604350},
  volume       = {98},
  year         = {2008},
}