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Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts.

Widerberg, Annika LU ; Kanje, Martin LU and Dahlin, Lars LU (2002) In NeuroReport 13(4). p.371-375
Abstract
One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to... (More)
One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts. (Less)
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type
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publication status
published
subject
keywords
Nerve Regeneration: physiology, Rats, Receptor, Animal, Female, Graft Survival: physiology, Wistar, Nerve Growth Factor: physiology, Sciatic Nerve: injuries, Sciatic Nerve: physiology, Sciatic Nerve: transplantation, Support, Non-U.S. Gov't, Tourniquets, Transplants
in
NeuroReport
volume
13
issue
4
pages
371 - 375
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:11930143
  • wos:000174971300002
  • scopus:0037171086
ISSN
1473-558X
DOI
10.1097/00001756-200203250-00002
language
English
LU publication?
yes
id
15640526-e109-4436-a1ad-34585f3e97c9 (old id 115459)
date added to LUP
2016-04-01 11:46:52
date last changed
2020-09-07 08:15:46
@article{15640526-e109-4436-a1ad-34585f3e97c9,
  abstract     = {One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts.},
  author       = {Widerberg, Annika and Kanje, Martin and Dahlin, Lars},
  issn         = {1473-558X},
  language     = {eng},
  number       = {4},
  pages        = {371--375},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts.},
  url          = {http://dx.doi.org/10.1097/00001756-200203250-00002},
  doi          = {10.1097/00001756-200203250-00002},
  volume       = {13},
  year         = {2002},
}