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Contrast media as markers of GFR

Frennby, Bo LU and Sterner, Gunnar LU (2002) In European Radiology 12(2). p.475-484
Abstract
Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and... (More)
Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and pregnant women and the safety in handling radiolabelled markers have led to an increasing interest in using non-radioactive markers. The development of simple and reliable methods to determine the concentration of contrast media in plasma and urine, such as high-performance liquid chromatography (HPLC) and X-ray fluorescence analysis have made this possible. The non-ionic low osmolar contrast medium iohexol has become the most commonly used contrast medium for GFR measurements in Europe. However, other contrast media with similar pharmacokinetics may be equally suitable as GFR markers. (Less)
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Contribution to journal
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published
subject
keywords
Inulin: diagnostic use, Kidney: physiology, Female, Glomerular Filtration Rate, Human, Child, Chromium Radioisotopes: diagnostic use, Contrast Media, Edetic Acid: diagnostic use, Male, Models, Theoretical, Pregnancy, Radiopharmaceuticals: diagnostic use, Technetium Tc 99m Pentetate: diagnostic use
in
European Radiology
volume
12
issue
2
pages
475 - 484
publisher
Springer
external identifiers
  • wos:000174127700033
  • pmid:11870453
  • scopus:0036484461
ISSN
0938-7994
DOI
10.1007/s003300100864
language
English
LU publication?
yes
id
1f23223d-ab37-4364-a4a0-2b1c39c3986c (old id 115548)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11870453&dopt=Abstract
date added to LUP
2007-07-04 16:43:38
date last changed
2017-06-25 04:35:47
@article{1f23223d-ab37-4364-a4a0-2b1c39c3986c,
  abstract     = {Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and pregnant women and the safety in handling radiolabelled markers have led to an increasing interest in using non-radioactive markers. The development of simple and reliable methods to determine the concentration of contrast media in plasma and urine, such as high-performance liquid chromatography (HPLC) and X-ray fluorescence analysis have made this possible. The non-ionic low osmolar contrast medium iohexol has become the most commonly used contrast medium for GFR measurements in Europe. However, other contrast media with similar pharmacokinetics may be equally suitable as GFR markers.},
  author       = {Frennby, Bo and Sterner, Gunnar},
  issn         = {0938-7994},
  keyword      = {Inulin: diagnostic use,Kidney: physiology,Female,Glomerular Filtration Rate,Human,Child,Chromium Radioisotopes: diagnostic use,Contrast Media,Edetic Acid: diagnostic use,Male,Models,Theoretical,Pregnancy,Radiopharmaceuticals: diagnostic use,Technetium Tc 99m Pentetate: diagnostic use},
  language     = {eng},
  number       = {2},
  pages        = {475--484},
  publisher    = {Springer},
  series       = {European Radiology},
  title        = {Contrast media as markers of GFR},
  url          = {http://dx.doi.org/10.1007/s003300100864},
  volume       = {12},
  year         = {2002},
}