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Improved Cognitive Development Among Preterm Infants Attributable to Early Supplementation of Human Milk With Docosahexaenoic Acid and Arachidonic Acid

Henriksen, Christine; Haugholt, Kristin; Lindgren, Magnus LU ; Aurvåg, Anne Karin; Rønnestad, Arild; Grønn, Morten; Solberg, Rønnaug; Moen, Atle; Nakstad, Britt and Berge, Rolf Kristian, et al. (2008) In Pediatrics 121(6). p.1137-1145
Abstract
OBJECTIVE. The objective of our study was to evaluate the effect of supplementation

with docosahexaenoic acid and arachidonic acid for human milk-fed preterm infants.

The primary end point was cognitive development at 6 months of age.

METHODS. The study was a randomized, double-blind, placebo-controlled study among

141 infants with birth weights of <1500 g. The intervention with 32 mg of docosahexaenoic

acid and 31 mg of arachidonic acid per 100 mL of human milk started 1

week after birth and lasted until discharge from the hospital (on average, 9 weeks).

Cognitive development was evaluated at 6 months of age by using the Ages and

Stages Questionnaire and... (More)
OBJECTIVE. The objective of our study was to evaluate the effect of supplementation

with docosahexaenoic acid and arachidonic acid for human milk-fed preterm infants.

The primary end point was cognitive development at 6 months of age.

METHODS. The study was a randomized, double-blind, placebo-controlled study among

141 infants with birth weights of <1500 g. The intervention with 32 mg of docosahexaenoic

acid and 31 mg of arachidonic acid per 100 mL of human milk started 1

week after birth and lasted until discharge from the hospital (on average, 9 weeks).

Cognitive development was evaluated at 6 months of age by using the Ages and

Stages Questionnaire and event-related potentials, a measure of brain correlates

related to recognition memory.

RESULTS. There was no difference in adverse events or growth between the 2 groups. At

the 6-month follow-up evaluation, the intervention group performed better on the

problem-solving subscore, compared with the control group (53.4 vs 49.5 points).

There was also a nonsignificant higher total score (221 vs 215 points). The eventrelated

potential data revealed that infants in the intervention group had significantly

lower responses after the standard image, compared with the control group

(8.6 vs 13.2). There was no difference in responses to novel images.

CONCLUSIONS. Supplementation with docosahexaenoic acid and arachidonic acid for

very preterm infants fed human milk in the early neonatal period was associated

with better recognition memory and higher problem-solving scores at 6 months (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
very low birth weight, preterm infants, human milk, fatty acids, developmental outcomes
in
Pediatrics
volume
121
issue
6
pages
1137 - 1145
publisher
American Academy of Pediatrics
external identifiers
  • wos:000256313700044
  • scopus:48949102177
ISSN
1098-4275
DOI
10.1542/peds.2007-1511
language
English
LU publication?
yes
id
de218e30-f628-4c11-9524-53f13d89d786 (old id 1157172)
date added to LUP
2008-06-11 12:55:26
date last changed
2017-09-17 04:56:14
@article{de218e30-f628-4c11-9524-53f13d89d786,
  abstract     = {OBJECTIVE. The objective of our study was to evaluate the effect of supplementation<br/><br>
with docosahexaenoic acid and arachidonic acid for human milk-fed preterm infants.<br/><br>
The primary end point was cognitive development at 6 months of age.<br/><br>
METHODS. The study was a randomized, double-blind, placebo-controlled study among<br/><br>
141 infants with birth weights of &lt;1500 g. The intervention with 32 mg of docosahexaenoic<br/><br>
acid and 31 mg of arachidonic acid per 100 mL of human milk started 1<br/><br>
week after birth and lasted until discharge from the hospital (on average, 9 weeks).<br/><br>
Cognitive development was evaluated at 6 months of age by using the Ages and<br/><br>
Stages Questionnaire and event-related potentials, a measure of brain correlates<br/><br>
related to recognition memory.<br/><br>
RESULTS. There was no difference in adverse events or growth between the 2 groups. At<br/><br>
the 6-month follow-up evaluation, the intervention group performed better on the<br/><br>
problem-solving subscore, compared with the control group (53.4 vs 49.5 points).<br/><br>
There was also a nonsignificant higher total score (221 vs 215 points). The eventrelated<br/><br>
potential data revealed that infants in the intervention group had significantly<br/><br>
lower responses after the standard image, compared with the control group<br/><br>
(8.6 vs 13.2). There was no difference in responses to novel images.<br/><br>
CONCLUSIONS. Supplementation with docosahexaenoic acid and arachidonic acid for<br/><br>
very preterm infants fed human milk in the early neonatal period was associated<br/><br>
with better recognition memory and higher problem-solving scores at 6 months},
  author       = {Henriksen, Christine and Haugholt, Kristin and Lindgren, Magnus and Aurvåg, Anne Karin and Rønnestad, Arild and Grønn, Morten and Solberg, Rønnaug and Moen, Atle and Nakstad, Britt and Berge, Rolf Kristian and Smith, Lars and Iversen, Per Ole and Drevon, Christian André},
  issn         = {1098-4275},
  keyword      = {very low birth
weight,preterm infants,human milk,fatty acids,developmental outcomes},
  language     = {eng},
  number       = {6},
  pages        = {1137--1145},
  publisher    = {American Academy of Pediatrics},
  series       = {Pediatrics},
  title        = {Improved Cognitive Development Among Preterm Infants Attributable to Early Supplementation of Human Milk With Docosahexaenoic Acid and Arachidonic Acid},
  url          = {http://dx.doi.org/10.1542/peds.2007-1511},
  volume       = {121},
  year         = {2008},
}