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Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.

Lueders, Florian LU ; Segawa, Hiroaki; Stein, David; Selva, Erica M.; Perrimon, Norbert; Turco, Salvatore J. and Häcker, Udo LU (2003) In EMBO Journal 22(14). p.3635-3644
Abstract
Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in this gene, which we call slalom, display defects in Wg and Hh signaling, which are likely due to the lack of sulfation of glycos aminoglycans by the sulfotransferase sulfateless. Analysis of mosaic mutant ovaries shows that sll function is also essential for dorsal–ventral axis determination, suggesting that sll transports the sulfate donor... (More)
Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in this gene, which we call slalom, display defects in Wg and Hh signaling, which are likely due to the lack of sulfation of glycos aminoglycans by the sulfotransferase sulfateless. Analysis of mosaic mutant ovaries shows that sll function is also essential for dorsal–ventral axis determination, suggesting that sll transports the sulfate donor required for sulfotransferase activity of the dorsal–ventral determinant pipe. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
sulfation, Pipe, glycosaminoglycan, Hedgehog, Wingless
in
EMBO Journal
volume
22
issue
14
pages
3635 - 3644
publisher
Oxford University Press
external identifiers
  • wos:000184385700017
  • pmid:12853478
  • scopus:0041813261
ISSN
1460-2075
DOI
language
English
LU publication?
yes
id
4d86688c-9fe9-4edb-a133-c3abc50ac61f (old id 116467)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12853478&dopt=Abstract
date added to LUP
2007-07-17 11:28:52
date last changed
2018-05-29 10:10:01
@article{4d86688c-9fe9-4edb-a133-c3abc50ac61f,
  abstract     = {Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in this gene, which we call slalom, display defects in Wg and Hh signaling, which are likely due to the lack of sulfation of glycos aminoglycans by the sulfotransferase sulfateless. Analysis of mosaic mutant ovaries shows that sll function is also essential for dorsal–ventral axis determination, suggesting that sll transports the sulfate donor required for sulfotransferase activity of the dorsal–ventral determinant pipe.},
  author       = {Lueders, Florian and Segawa, Hiroaki and Stein, David and Selva, Erica M. and Perrimon, Norbert and Turco, Salvatore J. and Häcker, Udo},
  issn         = {1460-2075},
  keyword      = {sulfation,Pipe,glycosaminoglycan,Hedgehog,Wingless},
  language     = {eng},
  number       = {14},
  pages        = {3635--3644},
  publisher    = {Oxford University Press},
  series       = {EMBO Journal},
  title        = {Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.},
  url          = {http://dx.doi.org/},
  volume       = {22},
  year         = {2003},
}