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Regional cerebral blood flow and EEG in clinically diagnosed dementia with Lewy bodies and Alzheimer's disease.

Londos, Elisabet LU ; Passant, Ulla LU ; Brun, Arne LU ; Rosén, Ingmar LU ; Risberg, Jarl LU and Gustafson, Lars LU (2003) In Archives of Gerontology and Geriatrics 36(3). p.231-245
Abstract
This study was undertaken in order to compare regional cerebral blood now (rCBF) and EEG findings of patients with clinically diagnosed dementia with Lewy bodies (clinDLB) and Alzheimer’s disease (clinAD). Furthermore, within the clinDLB group to compare cases with and without neuropathologically verified Lewy bodies (LBs). When we studied 200 dementia cases in a prospective longitudinal dementia study, 48 had clinDLB and 45 clinAD in retrospective analyses. EEG information was analysed in 34 clinDLB and 28 clinAD patients and cerebral blood flow, measured with the Xe 133 inhalation method, in 26 clinDLB and 25 clinAD. There were no differences in EEG between the clinDLB and clinAD groups or between the cases with and without LBs. The rCBF... (More)
This study was undertaken in order to compare regional cerebral blood now (rCBF) and EEG findings of patients with clinically diagnosed dementia with Lewy bodies (clinDLB) and Alzheimer’s disease (clinAD). Furthermore, within the clinDLB group to compare cases with and without neuropathologically verified Lewy bodies (LBs). When we studied 200 dementia cases in a prospective longitudinal dementia study, 48 had clinDLB and 45 clinAD in retrospective analyses. EEG information was analysed in 34 clinDLB and 28 clinAD patients and cerebral blood flow, measured with the Xe 133 inhalation method, in 26 clinDLB and 25 clinAD. There were no differences in EEG between the clinDLB and clinAD groups or between the cases with and without LBs. The rCBF patterns in the clinDLB and clinAD groups showed similar reductions in the temporoparietal areas. The rCBF in cases with LBs showed heterogeneous pathology. The imaging results in clinDLB and clinAD were strikingly similar. The EEG and rCBF could not differentiate between cases with or without LB. The study illustrates the lack of specific changes of EEG and rCBF in cases with LB pathology. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dementia with Lewy bodies, Alzheimer's disease, EEG, Regional cerebral blood flow, Lewy bodies
in
Archives of Gerontology and Geriatrics
volume
36
issue
3
pages
231 - 245
publisher
Elsevier
external identifiers
  • wos:000182763800003
  • scopus:0037405402
ISSN
1872-6976
DOI
10.1016/S0167-4943(02)00168-1
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychology (012010000), Department of Psychogeriatrics (013304000), Clinical Neurophysiology (013013001), Pathology, (Lund) (013030000), Clinical Memory Research Unit (013242610)
id
a20bd1c7-6e54-41f3-ba4c-4c3775689585 (old id 116768)
date added to LUP
2016-04-01 15:54:21
date last changed
2020-09-23 05:19:52
@article{a20bd1c7-6e54-41f3-ba4c-4c3775689585,
  abstract     = {This study was undertaken in order to compare regional cerebral blood now (rCBF) and EEG findings of patients with clinically diagnosed dementia with Lewy bodies (clinDLB) and Alzheimer’s disease (clinAD). Furthermore, within the clinDLB group to compare cases with and without neuropathologically verified Lewy bodies (LBs). When we studied 200 dementia cases in a prospective longitudinal dementia study, 48 had clinDLB and 45 clinAD in retrospective analyses. EEG information was analysed in 34 clinDLB and 28 clinAD patients and cerebral blood flow, measured with the Xe 133 inhalation method, in 26 clinDLB and 25 clinAD. There were no differences in EEG between the clinDLB and clinAD groups or between the cases with and without LBs. The rCBF patterns in the clinDLB and clinAD groups showed similar reductions in the temporoparietal areas. The rCBF in cases with LBs showed heterogeneous pathology. The imaging results in clinDLB and clinAD were strikingly similar. The EEG and rCBF could not differentiate between cases with or without LB. The study illustrates the lack of specific changes of EEG and rCBF in cases with LB pathology.},
  author       = {Londos, Elisabet and Passant, Ulla and Brun, Arne and Rosén, Ingmar and Risberg, Jarl and Gustafson, Lars},
  issn         = {1872-6976},
  language     = {eng},
  number       = {3},
  pages        = {231--245},
  publisher    = {Elsevier},
  series       = {Archives of Gerontology and Geriatrics},
  title        = {Regional cerebral blood flow and EEG in clinically diagnosed dementia with Lewy bodies and Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1016/S0167-4943(02)00168-1},
  doi          = {10.1016/S0167-4943(02)00168-1},
  volume       = {36},
  year         = {2003},
}