Haemophilia in the first years of life.
Ljung, Rolf LU
; Chambost, H
; Stain, A-M
and DiMichele, D
(2008)
In Haemophilia
14 Suppl 3.
p.188-195
- Abstract
- Surgery in infants and young children with haemophilia, when preceded by accurate diagnosis and accompanied by safe and effective factor prophylaxis, is not associated with a significant risk of haemorrhage. Haemophilic newborns undergoing circumcision or major surgery prior to diagnosis and in the absence of appropriate haemostatic prophylaxis remain as a concern. Inhibitor development has replaced haemorrhage as the major surgical complication in the developed world, largely because of the intensity of treatment used to secure haemostasis. For that reason only, essential surgery should be performed. Intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys in countries with a good standard of... (More)
- Surgery in infants and young children with haemophilia, when preceded by accurate diagnosis and accompanied by safe and effective factor prophylaxis, is not associated with a significant risk of haemorrhage. Haemophilic newborns undergoing circumcision or major surgery prior to diagnosis and in the absence of appropriate haemostatic prophylaxis remain as a concern. Inhibitor development has replaced haemorrhage as the major surgical complication in the developed world, largely because of the intensity of treatment used to secure haemostasis. For that reason only, essential surgery should be performed. Intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys in countries with a good standard of health care, which is considerably (40-80 times) higher than expected in the normal population. Because of the high frequency of sporadic cases, ICH in the neonatal period can only be partially prevented by improved carrier diagnosis and counselling. Infections and thrombosis are the major serious complications of central venous lines. Large differences are seen in the frequency of these complications, the most plausible explanations are probably related to the protocol used for device care, the quality of education and the compliance of the users, an issue addressed in an on-going study. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1168563
- author
- Ljung, Rolf
LU
; Chambost, H
; Stain, A-M
and DiMichele, D
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Haemophilia
- volume
- 14 Suppl 3
- pages
- 188 - 195
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000256185300027
- pmid:18510541
- scopus:44249099931
- pmid:18510541
- ISSN
- 1351-8216
- DOI
- 10.1111/j.1365-2516.2008.01722.x
- language
- English
- LU publication?
- yes
- id
- 0ebda0ef-e34f-4231-9da9-49664922ba7e (old id 1168563)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18510541?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:57
- date last changed
- 2022-07-10 05:28:02
@article{0ebda0ef-e34f-4231-9da9-49664922ba7e,
abstract = {{Surgery in infants and young children with haemophilia, when preceded by accurate diagnosis and accompanied by safe and effective factor prophylaxis, is not associated with a significant risk of haemorrhage. Haemophilic newborns undergoing circumcision or major surgery prior to diagnosis and in the absence of appropriate haemostatic prophylaxis remain as a concern. Inhibitor development has replaced haemorrhage as the major surgical complication in the developed world, largely because of the intensity of treatment used to secure haemostasis. For that reason only, essential surgery should be performed. Intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys in countries with a good standard of health care, which is considerably (40-80 times) higher than expected in the normal population. Because of the high frequency of sporadic cases, ICH in the neonatal period can only be partially prevented by improved carrier diagnosis and counselling. Infections and thrombosis are the major serious complications of central venous lines. Large differences are seen in the frequency of these complications, the most plausible explanations are probably related to the protocol used for device care, the quality of education and the compliance of the users, an issue addressed in an on-going study.}},
author = {{Ljung, Rolf and Chambost, H and Stain, A-M and DiMichele, D}},
issn = {{1351-8216}},
language = {{eng}},
pages = {{188--195}},
publisher = {{Wiley-Blackwell}},
series = {{Haemophilia}},
title = {{Haemophilia in the first years of life.}},
url = {{http://dx.doi.org/10.1111/j.1365-2516.2008.01722.x}},
doi = {{10.1111/j.1365-2516.2008.01722.x}},
volume = {{14 Suppl 3}},
year = {{2008}},
}