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Inhibitor development.

Astermark, Jan LU ; Lacroix-Desmazes, S and Reding, M T (2008) In Haemophilia 14 Suppl 3. p.36-42
Abstract
The immune response to factor VIII and the development of inhibitory antibodies is a complex multi-factorial process involving a variety of immune regulatory genes and cells, several of which have the potential to determine risk. A better understanding of the mechanisms involved will increase the likelihood of development of new therapeutic options for patients with hemophilia. This review summarizes genetic and non-genetic risk factors currently under evaluation, and the potential modulative effect of the von Willebrand factor on factor VIII immuno- and antigenicity. In addition, the role of T-regulatory cells in the pathogenicity of inhibitors will be discussed.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haemophilia
volume
14 Suppl 3
pages
36 - 42
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000256185300006
  • pmid:18510520
  • scopus:44249094890
ISSN
1351-8216
DOI
10.1111/j.1365-2516.2008.01711.x
language
English
LU publication?
yes
id
049fd55e-e4bf-451d-81f9-314ec59a0ab5 (old id 1168570)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18510520?dopt=Abstract
date added to LUP
2008-07-02 14:51:39
date last changed
2017-07-30 04:50:34
@article{049fd55e-e4bf-451d-81f9-314ec59a0ab5,
  abstract     = {The immune response to factor VIII and the development of inhibitory antibodies is a complex multi-factorial process involving a variety of immune regulatory genes and cells, several of which have the potential to determine risk. A better understanding of the mechanisms involved will increase the likelihood of development of new therapeutic options for patients with hemophilia. This review summarizes genetic and non-genetic risk factors currently under evaluation, and the potential modulative effect of the von Willebrand factor on factor VIII immuno- and antigenicity. In addition, the role of T-regulatory cells in the pathogenicity of inhibitors will be discussed.},
  author       = {Astermark, Jan and Lacroix-Desmazes, S and Reding, M T},
  issn         = {1351-8216},
  language     = {eng},
  pages        = {36--42},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {Inhibitor development.},
  url          = {http://dx.doi.org/10.1111/j.1365-2516.2008.01711.x},
  volume       = {14 Suppl 3},
  year         = {2008},
}