Inhibitor development.
(2008) In Haemophilia 14 Suppl 3. p.36-42- Abstract
- The immune response to factor VIII and the development of inhibitory antibodies is a complex multi-factorial process involving a variety of immune regulatory genes and cells, several of which have the potential to determine risk. A better understanding of the mechanisms involved will increase the likelihood of development of new therapeutic options for patients with hemophilia. This review summarizes genetic and non-genetic risk factors currently under evaluation, and the potential modulative effect of the von Willebrand factor on factor VIII immuno- and antigenicity. In addition, the role of T-regulatory cells in the pathogenicity of inhibitors will be discussed.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1168570
- author
- Astermark, Jan LU ; Lacroix-Desmazes, S and Reding, M T
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Haemophilia
- volume
- 14 Suppl 3
- pages
- 36 - 42
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000256185300006
- pmid:18510520
- scopus:44249094890
- ISSN
- 1351-8216
- DOI
- 10.1111/j.1365-2516.2008.01711.x
- language
- English
- LU publication?
- yes
- id
- 049fd55e-e4bf-451d-81f9-314ec59a0ab5 (old id 1168570)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18510520?dopt=Abstract
- date added to LUP
- 2016-04-04 08:33:33
- date last changed
- 2022-08-30 18:12:55
@article{049fd55e-e4bf-451d-81f9-314ec59a0ab5,
abstract = {{The immune response to factor VIII and the development of inhibitory antibodies is a complex multi-factorial process involving a variety of immune regulatory genes and cells, several of which have the potential to determine risk. A better understanding of the mechanisms involved will increase the likelihood of development of new therapeutic options for patients with hemophilia. This review summarizes genetic and non-genetic risk factors currently under evaluation, and the potential modulative effect of the von Willebrand factor on factor VIII immuno- and antigenicity. In addition, the role of T-regulatory cells in the pathogenicity of inhibitors will be discussed.}},
author = {{Astermark, Jan and Lacroix-Desmazes, S and Reding, M T}},
issn = {{1351-8216}},
language = {{eng}},
pages = {{36--42}},
publisher = {{Wiley-Blackwell}},
series = {{Haemophilia}},
title = {{Inhibitor development.}},
url = {{http://dx.doi.org/10.1111/j.1365-2516.2008.01711.x}},
doi = {{10.1111/j.1365-2516.2008.01711.x}},
volume = {{14 Suppl 3}},
year = {{2008}},
}