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The role of desmin in active force transmission and maintenance of structure during growth of urinary bladder.

Scott, Rolf Sjuve; Li, Zhenlin; Paulin, Denise; Uvelius, Bengt LU ; Small, J Victor and Arner, Anders LU (2008) In American Journal of Physiology: Cell Physiology 295(2). p.324-331
Abstract
The role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin deficient mice (Des -/-). A partial obstruction of the urethra was created and after 9-19 days bladder weight increased about 3-fold in both Des -/- and wild type (Des +/+) animals. Bladder growth was associated with synthesis of actin and myosin. In the hypertrophic Des +/+ bladder the relative content of desmin increased. In Des -/- mice desmin was absent. No alterations in the amount of vimentin were observed. Although Des -/- obstructed bladders were capable of growth they had structural changes with partial disruption of the wall. Des-/- bladders had slightly lower passive stress and significantly lower active stress compared to... (More)
The role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin deficient mice (Des -/-). A partial obstruction of the urethra was created and after 9-19 days bladder weight increased about 3-fold in both Des -/- and wild type (Des +/+) animals. Bladder growth was associated with synthesis of actin and myosin. In the hypertrophic Des +/+ bladder the relative content of desmin increased. In Des -/- mice desmin was absent. No alterations in the amount of vimentin were observed. Although Des -/- obstructed bladders were capable of growth they had structural changes with partial disruption of the wall. Des-/- bladders had slightly lower passive stress and significantly lower active stress compared to Des+/+. Des-/- preparations had lower shortening velocity. During hypertrophy these structural and mechanical alterations in the Des-/- urinary bladder became more pronounced. In conclusion, desmin in the bladder smooth muscle is not needed for growth but has a role in active force transmission and maintenance of wall structure. Key words: smooth muscle, intermediate filaments, desmin, transgenic. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intermediate filaments, smooth muscle, hypertrophy, transgenic mice
in
American Journal of Physiology: Cell Physiology
volume
295
issue
2
pages
324 - 331
publisher
American Physiological Society
external identifiers
  • wos:000258992200005
  • pmid:18562479
  • scopus:55949127002
ISSN
1522-1563
DOI
10.1152/ajpcell.90622.2007
language
English
LU publication?
yes
id
0eaa6732-f2fb-4e5e-95b7-c9f578ba1ad7 (old id 1168708)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18562479?dopt=Abstract
date added to LUP
2008-07-04 11:07:55
date last changed
2017-07-09 03:52:20
@article{0eaa6732-f2fb-4e5e-95b7-c9f578ba1ad7,
  abstract     = {The role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin deficient mice (Des -/-). A partial obstruction of the urethra was created and after 9-19 days bladder weight increased about 3-fold in both Des -/- and wild type (Des +/+) animals. Bladder growth was associated with synthesis of actin and myosin. In the hypertrophic Des +/+ bladder the relative content of desmin increased. In Des -/- mice desmin was absent. No alterations in the amount of vimentin were observed. Although Des -/- obstructed bladders were capable of growth they had structural changes with partial disruption of the wall. Des-/- bladders had slightly lower passive stress and significantly lower active stress compared to Des+/+. Des-/- preparations had lower shortening velocity. During hypertrophy these structural and mechanical alterations in the Des-/- urinary bladder became more pronounced. In conclusion, desmin in the bladder smooth muscle is not needed for growth but has a role in active force transmission and maintenance of wall structure. Key words: smooth muscle, intermediate filaments, desmin, transgenic.},
  author       = {Scott, Rolf Sjuve and Li, Zhenlin and Paulin, Denise and Uvelius, Bengt and Small, J Victor and Arner, Anders},
  issn         = {1522-1563},
  keyword      = {intermediate filaments,smooth muscle,hypertrophy,transgenic mice},
  language     = {eng},
  number       = {2},
  pages        = {324--331},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Cell Physiology},
  title        = {The role of desmin in active force transmission and maintenance of structure during growth of urinary bladder.},
  url          = {http://dx.doi.org/10.1152/ajpcell.90622.2007},
  volume       = {295},
  year         = {2008},
}