The role of desmin in active force transmission and maintenance of structure during growth of urinary bladder.
(2008) In American Journal of Physiology: Cell Physiology 295(2). p.324-331- Abstract
- The role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin deficient mice (Des -/-). A partial obstruction of the urethra was created and after 9-19 days bladder weight increased about 3-fold in both Des -/- and wild type (Des +/+) animals. Bladder growth was associated with synthesis of actin and myosin. In the hypertrophic Des +/+ bladder the relative content of desmin increased. In Des -/- mice desmin was absent. No alterations in the amount of vimentin were observed. Although Des -/- obstructed bladders were capable of growth they had structural changes with partial disruption of the wall. Des-/- bladders had slightly lower passive stress and significantly lower active stress compared to... (More)
- The role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin deficient mice (Des -/-). A partial obstruction of the urethra was created and after 9-19 days bladder weight increased about 3-fold in both Des -/- and wild type (Des +/+) animals. Bladder growth was associated with synthesis of actin and myosin. In the hypertrophic Des +/+ bladder the relative content of desmin increased. In Des -/- mice desmin was absent. No alterations in the amount of vimentin were observed. Although Des -/- obstructed bladders were capable of growth they had structural changes with partial disruption of the wall. Des-/- bladders had slightly lower passive stress and significantly lower active stress compared to Des+/+. Des-/- preparations had lower shortening velocity. During hypertrophy these structural and mechanical alterations in the Des-/- urinary bladder became more pronounced. In conclusion, desmin in the bladder smooth muscle is not needed for growth but has a role in active force transmission and maintenance of wall structure. Key words: smooth muscle, intermediate filaments, desmin, transgenic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1168708
- author
- Scott, Rolf Sjuve ; Li, Zhenlin ; Paulin, Denise ; Uvelius, Bengt LU ; Small, J Victor and Arner, Anders LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- intermediate filaments, smooth muscle, hypertrophy, transgenic mice
- in
- American Journal of Physiology: Cell Physiology
- volume
- 295
- issue
- 2
- pages
- 324 - 331
- publisher
- American Physiological Society
- external identifiers
-
- wos:000258992200005
- pmid:18562479
- scopus:55949127002
- ISSN
- 1522-1563
- DOI
- 10.1152/ajpcell.90622.2007
- language
- English
- LU publication?
- yes
- id
- 0eaa6732-f2fb-4e5e-95b7-c9f578ba1ad7 (old id 1168708)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18562479?dopt=Abstract
- date added to LUP
- 2016-04-01 13:08:11
- date last changed
- 2022-01-27 17:34:12
@article{0eaa6732-f2fb-4e5e-95b7-c9f578ba1ad7,
abstract = {{The role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin deficient mice (Des -/-). A partial obstruction of the urethra was created and after 9-19 days bladder weight increased about 3-fold in both Des -/- and wild type (Des +/+) animals. Bladder growth was associated with synthesis of actin and myosin. In the hypertrophic Des +/+ bladder the relative content of desmin increased. In Des -/- mice desmin was absent. No alterations in the amount of vimentin were observed. Although Des -/- obstructed bladders were capable of growth they had structural changes with partial disruption of the wall. Des-/- bladders had slightly lower passive stress and significantly lower active stress compared to Des+/+. Des-/- preparations had lower shortening velocity. During hypertrophy these structural and mechanical alterations in the Des-/- urinary bladder became more pronounced. In conclusion, desmin in the bladder smooth muscle is not needed for growth but has a role in active force transmission and maintenance of wall structure. Key words: smooth muscle, intermediate filaments, desmin, transgenic.}},
author = {{Scott, Rolf Sjuve and Li, Zhenlin and Paulin, Denise and Uvelius, Bengt and Small, J Victor and Arner, Anders}},
issn = {{1522-1563}},
keywords = {{intermediate filaments; smooth muscle; hypertrophy; transgenic mice}},
language = {{eng}},
number = {{2}},
pages = {{324--331}},
publisher = {{American Physiological Society}},
series = {{American Journal of Physiology: Cell Physiology}},
title = {{The role of desmin in active force transmission and maintenance of structure during growth of urinary bladder.}},
url = {{http://dx.doi.org/10.1152/ajpcell.90622.2007}},
doi = {{10.1152/ajpcell.90622.2007}},
volume = {{295}},
year = {{2008}},
}