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Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats.

Dahlin, Lars LU ; Stenberg, Lena LU ; Luthman, Holger LU and Thomsen, Niels LU (2008) In NeuroReport 19(9). p.987-990
Abstract
Expression of transcription factor ATF3 in sensory neurons in dorsal root ganglion and in Schwann cells in sciatic nerve of diabetic (BB and Goto-Kakizaki rats; experimental models of types 1 and 2 diabetes, respectively) and healthy rats were examined by immunocytochemistry after nerve compression (silicone tube) for 3, 6 or 14 days. ATF3-stained sensory neurons in dorsal root ganglia and Schwann cells at compression site were more frequent in diabetic BB rats. Decompression of nerves in Goto-Kakizaki rats did not reduce number of ATF3-stained cells. Diabetes (BB; i.e. type 1) confers on the peripheral nerve an increased susceptibility to nerve compression indicated by an increased expression of stained ATF3 neurons and Schwann cells.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
19
issue
9
pages
987 - 990
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000256741800017
  • pmid:18521006
  • scopus:52249089449
ISSN
1473-558X
DOI
10.1097/WNR.0b013e328302f4ec
language
English
LU publication?
yes
id
ed5ead33-fcf4-4736-8b40-971319b1c677 (old id 1169296)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18521006?dopt=Abstract
date added to LUP
2008-07-03 09:36:02
date last changed
2017-06-11 04:38:39
@article{ed5ead33-fcf4-4736-8b40-971319b1c677,
  abstract     = {Expression of transcription factor ATF3 in sensory neurons in dorsal root ganglion and in Schwann cells in sciatic nerve of diabetic (BB and Goto-Kakizaki rats; experimental models of types 1 and 2 diabetes, respectively) and healthy rats were examined by immunocytochemistry after nerve compression (silicone tube) for 3, 6 or 14 days. ATF3-stained sensory neurons in dorsal root ganglia and Schwann cells at compression site were more frequent in diabetic BB rats. Decompression of nerves in Goto-Kakizaki rats did not reduce number of ATF3-stained cells. Diabetes (BB; i.e. type 1) confers on the peripheral nerve an increased susceptibility to nerve compression indicated by an increased expression of stained ATF3 neurons and Schwann cells.},
  author       = {Dahlin, Lars and Stenberg, Lena and Luthman, Holger and Thomsen, Niels},
  issn         = {1473-558X},
  language     = {eng},
  number       = {9},
  pages        = {987--990},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats.},
  url          = {http://dx.doi.org/10.1097/WNR.0b013e328302f4ec},
  volume       = {19},
  year         = {2008},
}