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Association between findings on delayed gadolinium-enhanced magnetic resonance imaging of cartilage and future knee osteoarthritis.

Owman, Henrik LU ; Tiderius, Carl Johan LU ; Neuman, Paul LU ; Nyquist, Fredrik LU and Dahlberg, Leif LU (2008) In Arthritis and Rheumatism 58(6). p.1727-1730
Abstract
OBJECTIVE: To examine the predictive value of the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) index with regard to future radiographic osteoarthritis (OA). METHODS: In 1998, 17 knees in 11 men and 4 women with knee pain, normal results of weight-bearing radiography, and arthroscopic cartilage changes ranging from superficial fibrillation to fissuring and softening were examined using dGEMRIC. Six years later, 16 of the 17 knees were reassessed for radiographic OA changes. RESULTS: At followup, 9 of the 16 knees showed radiographic OA changes. Two of them had undergone a knee joint replacement due to OA. In the knees with radiographic OA, the dGEMRIC index at baseline was lower than that in the knees... (More)
OBJECTIVE: To examine the predictive value of the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) index with regard to future radiographic osteoarthritis (OA). METHODS: In 1998, 17 knees in 11 men and 4 women with knee pain, normal results of weight-bearing radiography, and arthroscopic cartilage changes ranging from superficial fibrillation to fissuring and softening were examined using dGEMRIC. Six years later, 16 of the 17 knees were reassessed for radiographic OA changes. RESULTS: At followup, 9 of the 16 knees showed radiographic OA changes. Two of them had undergone a knee joint replacement due to OA. In the knees with radiographic OA, the dGEMRIC index at baseline was lower than that in the knees without radiographic OA (P = 0.03). CONCLUSION: The results of the present study support the dGEMRIC index as a clinically relevant measure of cartilage integrity and suggest that a low index may be predictive of the development of knee OA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
58
issue
6
pages
1727 - 1730
publisher
John Wiley & Sons
external identifiers
  • wos:000256724900020
  • pmid:18512778
  • scopus:45349094375
ISSN
1529-0131
DOI
10.1002/art.23459
language
English
LU publication?
yes
id
b4453f81-f083-42fa-868d-c3c678b291cc (old id 1169416)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18512778?dopt=Abstract
date added to LUP
2008-07-02 11:35:28
date last changed
2017-05-28 04:31:39
@article{b4453f81-f083-42fa-868d-c3c678b291cc,
  abstract     = {OBJECTIVE: To examine the predictive value of the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) index with regard to future radiographic osteoarthritis (OA). METHODS: In 1998, 17 knees in 11 men and 4 women with knee pain, normal results of weight-bearing radiography, and arthroscopic cartilage changes ranging from superficial fibrillation to fissuring and softening were examined using dGEMRIC. Six years later, 16 of the 17 knees were reassessed for radiographic OA changes. RESULTS: At followup, 9 of the 16 knees showed radiographic OA changes. Two of them had undergone a knee joint replacement due to OA. In the knees with radiographic OA, the dGEMRIC index at baseline was lower than that in the knees without radiographic OA (P = 0.03). CONCLUSION: The results of the present study support the dGEMRIC index as a clinically relevant measure of cartilage integrity and suggest that a low index may be predictive of the development of knee OA.},
  author       = {Owman, Henrik and Tiderius, Carl Johan and Neuman, Paul and Nyquist, Fredrik and Dahlberg, Leif},
  issn         = {1529-0131},
  language     = {eng},
  number       = {6},
  pages        = {1727--1730},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis and Rheumatism},
  title        = {Association between findings on delayed gadolinium-enhanced magnetic resonance imaging of cartilage and future knee osteoarthritis.},
  url          = {http://dx.doi.org/10.1002/art.23459},
  volume       = {58},
  year         = {2008},
}