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The role of CT-assessed sarcopenia and visceral adipose tissue in predicting long-term survival in patients undergoing elective endovascular infrarenal aortic repair

Vaccarino, Roberta LU ; Wachtmeister, Melker ; Karelis, Angelos LU orcid ; Marinko, Elisabet LU ; Sun, Jianming ; Resch, Timothy LU ; Sonesson, Björn LU and Dias, Nuno V. LU orcid (2024) In The British journal of radiology 97(1160). p.1461-1466
Abstract

OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT. Primary endpoint was all-cause mortality. Values are presented as median and interquartile range or absolute number and percentage. Cox regression analyses were performed to assess the associations with mortality. RESULTS: Two hundred and eighty-four patients could be included in the study. During a median follow-up of 8 (4-11) years, 223... (More)

OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT. Primary endpoint was all-cause mortality. Values are presented as median and interquartile range or absolute number and percentage. Cox regression analyses were performed to assess the associations with mortality. RESULTS: Two hundred and eighty-four patients could be included in the study. During a median follow-up of 8 (4-11) years, 223 (79.9%) patients died. Age (P ≤ .001), cardiovascular (P = .041), cerebrovascular (P = .009), renal diseases (P = .002), and chronic obstructive pulmonary disease (P ≤ .001) were independently associated with mortality. TPA was associated with mortality in a univariate (P = .040), but not in a multivariate regression model (P = .764). No significant association was found between mortality and TPA index (P = .103) or any of the adiposity measurements with the exception of SAT (P = .040). However, SAT area loss in a multivariate analysis (P = .875). CONCLUSIONS: Assessment of core muscle size and VAT did not contribute to improving the prediction of long-term survival after EVAR. ADVANCES IN KNOWLEDGE: The finding of this study contradicts the previously claimed utility of core muscle size and VAT in predicting long-term survival after EVAR.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
EVAR, ileo-psoas muscle size, preoperative risk assessment, visceral adipose tissue
in
The British journal of radiology
volume
97
issue
1160
pages
6 pages
publisher
British Institute of Radiology
external identifiers
  • pmid:38848475
  • scopus:85199224235
ISSN
1748-880X
DOI
10.1093/bjr/tqae114
language
English
LU publication?
yes
id
116ded4c-8ed0-4e21-a7e9-96e8659c8a8e
date added to LUP
2024-09-09 15:34:28
date last changed
2025-06-03 16:12:53
@article{116ded4c-8ed0-4e21-a7e9-96e8659c8a8e,
  abstract     = {{<p>OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT. Primary endpoint was all-cause mortality. Values are presented as median and interquartile range or absolute number and percentage. Cox regression analyses were performed to assess the associations with mortality. RESULTS: Two hundred and eighty-four patients could be included in the study. During a median follow-up of 8 (4-11) years, 223 (79.9%) patients died. Age (P ≤ .001), cardiovascular (P = .041), cerebrovascular (P = .009), renal diseases (P = .002), and chronic obstructive pulmonary disease (P ≤ .001) were independently associated with mortality. TPA was associated with mortality in a univariate (P = .040), but not in a multivariate regression model (P = .764). No significant association was found between mortality and TPA index (P = .103) or any of the adiposity measurements with the exception of SAT (P = .040). However, SAT area loss in a multivariate analysis (P = .875). CONCLUSIONS: Assessment of core muscle size and VAT did not contribute to improving the prediction of long-term survival after EVAR. ADVANCES IN KNOWLEDGE: The finding of this study contradicts the previously claimed utility of core muscle size and VAT in predicting long-term survival after EVAR.</p>}},
  author       = {{Vaccarino, Roberta and Wachtmeister, Melker and Karelis, Angelos and Marinko, Elisabet and Sun, Jianming and Resch, Timothy and Sonesson, Björn and Dias, Nuno V.}},
  issn         = {{1748-880X}},
  keywords     = {{EVAR; ileo-psoas muscle size; preoperative risk assessment; visceral adipose tissue}},
  language     = {{eng}},
  number       = {{1160}},
  pages        = {{1461--1466}},
  publisher    = {{British Institute of Radiology}},
  series       = {{The British journal of radiology}},
  title        = {{The role of CT-assessed sarcopenia and visceral adipose tissue in predicting long-term survival in patients undergoing elective endovascular infrarenal aortic repair}},
  url          = {{http://dx.doi.org/10.1093/bjr/tqae114}},
  doi          = {{10.1093/bjr/tqae114}},
  volume       = {{97}},
  year         = {{2024}},
}