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Myocardial topical negative pressure increases blood flow in hypothermic, ischemic myocardium.

Lindstedt Ingemansson, Sandra LU ; Johansson, Malin ; Hlebowicz, Joanna LU ; Malmsjö, Malin LU orcid and Ingemansson, Richard LU (2008) In Scandinavian Cardiovascular Journal 42. p.345-353
Abstract
Objectives. Hypothermia protects the myocardium from oxidative injury during ischemic stress and reperfusion. We have previously shown that topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of TNP between -50 mmHg and -150 mmHg on microvascular blood flow in ischemic myocardium during hypothermia. Design. The microvascular blood flow in the myocardium was recorded, in seven pigs, using laser Doppler velocimetry. Analyses were performed in the epicardium and in the myocardium, after 40 minutes of occlusion of the LAD followed by cooling to 31 degrees C.... (More)
Objectives. Hypothermia protects the myocardium from oxidative injury during ischemic stress and reperfusion. We have previously shown that topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of TNP between -50 mmHg and -150 mmHg on microvascular blood flow in ischemic myocardium during hypothermia. Design. The microvascular blood flow in the myocardium was recorded, in seven pigs, using laser Doppler velocimetry. Analyses were performed in the epicardium and in the myocardium, after 40 minutes of occlusion of the LAD followed by cooling to 31 degrees C. Results. A TNP of -50 mmHg applied to the epicardium, from 23.3+/-3.8 PU to 104.2+/-31.3 PU (*p <0.05), and in the myocardium, from 35.0+/-7.2 PU to 74.2+/-21.8 PU (*p <0.05). Conclusions. Only a TNP level of -50 mmHg significantly increased the microvascular blood flow in both the epicardium and in the myocardium during hypothermia. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Cardiovascular Journal
volume
42
pages
345 - 353
publisher
Taylor & Francis
external identifiers
  • wos:000259318400009
  • pmid:18609061
  • scopus:55449134389
  • pmid:18609061
ISSN
1651-2006
DOI
10.1080/14017430801939225
language
English
LU publication?
yes
id
21be2f1b-45a8-44f1-99f1-aa8994cc7a5a (old id 1181405)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18609061?dopt=Abstract
date added to LUP
2016-04-04 09:39:35
date last changed
2024-10-13 04:44:19
@article{21be2f1b-45a8-44f1-99f1-aa8994cc7a5a,
  abstract     = {{Objectives. Hypothermia protects the myocardium from oxidative injury during ischemic stress and reperfusion. We have previously shown that topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of TNP between -50 mmHg and -150 mmHg on microvascular blood flow in ischemic myocardium during hypothermia. Design. The microvascular blood flow in the myocardium was recorded, in seven pigs, using laser Doppler velocimetry. Analyses were performed in the epicardium and in the myocardium, after 40 minutes of occlusion of the LAD followed by cooling to 31 degrees C. Results. A TNP of -50 mmHg applied to the epicardium, from 23.3+/-3.8 PU to 104.2+/-31.3 PU (*p &lt;0.05), and in the myocardium, from 35.0+/-7.2 PU to 74.2+/-21.8 PU (*p &lt;0.05). Conclusions. Only a TNP level of -50 mmHg significantly increased the microvascular blood flow in both the epicardium and in the myocardium during hypothermia.}},
  author       = {{Lindstedt Ingemansson, Sandra and Johansson, Malin and Hlebowicz, Joanna and Malmsjö, Malin and Ingemansson, Richard}},
  issn         = {{1651-2006}},
  language     = {{eng}},
  pages        = {{345--353}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Cardiovascular Journal}},
  title        = {{Myocardial topical negative pressure increases blood flow in hypothermic, ischemic myocardium.}},
  url          = {{http://dx.doi.org/10.1080/14017430801939225}},
  doi          = {{10.1080/14017430801939225}},
  volume       = {{42}},
  year         = {{2008}},
}