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Improved accuracy in time-resolved diffuse reflectance spectroscopy.

Alerstam, Erik LU ; Andersson-Engels, Stefan LU and Svensson, Tomas LU (2008) In Optics Express 16(14). p.10440-10454
Abstract
Significant improvements in the accuracy of time-resolved diffuse reflectance spectroscopy are reached by using a Monte Carlo scheme for evaluation of measured photon time-of-flight distributions. The use of time-resolved diffusion theory of photon migration, being the current standard scheme for data evaluation, is shown defective. In particular, the familiar problem sometimes referred to as absorption-to-scattering coupling or crosstalk, is identified as an error related to the breakdown of the diffusion approximation. These systematic errors are investigated numerically using Monte Carlo simulations, and their influence on data evaluation of experimental recordings are accurately predicted. The proposed Monte Carlo-based data evaluation... (More)
Significant improvements in the accuracy of time-resolved diffuse reflectance spectroscopy are reached by using a Monte Carlo scheme for evaluation of measured photon time-of-flight distributions. The use of time-resolved diffusion theory of photon migration, being the current standard scheme for data evaluation, is shown defective. In particular, the familiar problem sometimes referred to as absorption-to-scattering coupling or crosstalk, is identified as an error related to the breakdown of the diffusion approximation. These systematic errors are investigated numerically using Monte Carlo simulations, and their influence on data evaluation of experimental recordings are accurately predicted. The proposed Monte Carlo-based data evaluation avoids these errors, and can be used for routine data evaluation. The accuracy and reproducibility of both MC and diffusion modeling are investigated experimentally using the MEDPHOT set of solid tissue-simulating phantoms, and provides convincing arguments that Monte Carlo-based evaluation is crucial in important ranges of optical properties. In contrast to diffusion-based evaluation, the Monte Carlo scheme results in optical properties consistent with phantom design. Since the MEDPHOT phantoms are used for international comparisons and performance assessment, the performed characterization is carefully reported. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
16
issue
14
pages
10440 - 10454
publisher
OSA
external identifiers
  • wos:000257564100050
  • pmid:18607457
  • scopus:55749094001
ISSN
1094-4087
DOI
10.1364/OE.16.010440
language
English
LU publication?
yes
id
cfce0217-760f-425b-8224-1731469cf56d (old id 1181480)
date added to LUP
2008-09-28 22:42:27
date last changed
2017-10-01 04:19:29
@article{cfce0217-760f-425b-8224-1731469cf56d,
  abstract     = {Significant improvements in the accuracy of time-resolved diffuse reflectance spectroscopy are reached by using a Monte Carlo scheme for evaluation of measured photon time-of-flight distributions. The use of time-resolved diffusion theory of photon migration, being the current standard scheme for data evaluation, is shown defective. In particular, the familiar problem sometimes referred to as absorption-to-scattering coupling or crosstalk, is identified as an error related to the breakdown of the diffusion approximation. These systematic errors are investigated numerically using Monte Carlo simulations, and their influence on data evaluation of experimental recordings are accurately predicted. The proposed Monte Carlo-based data evaluation avoids these errors, and can be used for routine data evaluation. The accuracy and reproducibility of both MC and diffusion modeling are investigated experimentally using the MEDPHOT set of solid tissue-simulating phantoms, and provides convincing arguments that Monte Carlo-based evaluation is crucial in important ranges of optical properties. In contrast to diffusion-based evaluation, the Monte Carlo scheme results in optical properties consistent with phantom design. Since the MEDPHOT phantoms are used for international comparisons and performance assessment, the performed characterization is carefully reported.},
  author       = {Alerstam, Erik and Andersson-Engels, Stefan and Svensson, Tomas},
  issn         = {1094-4087},
  language     = {eng},
  number       = {14},
  pages        = {10440--10454},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Improved accuracy in time-resolved diffuse reflectance spectroscopy.},
  url          = {http://dx.doi.org/10.1364/OE.16.010440},
  volume       = {16},
  year         = {2008},
}