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Emerging restorative treatments for Parkinson's disease.

Deierborg, Tomas LU ; Soulet, Denis LU ; Roybon, Laurent LU ; Hall, Vanessa LU and Brundin, Patrik LU (2008) In Progress in Neurobiology 85. p.407-432
Abstract
Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and... (More)
Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and embryonic stem cells, to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Progress in Neurobiology
volume
85
pages
407 - 432
publisher
Elsevier
external identifiers
  • wos:000259047900004
  • pmid:18586376
  • scopus:48549096880
ISSN
1873-5118
DOI
10.1016/j.pneurobio.2008.05.001
language
English
LU publication?
yes
id
3a4b07c5-65df-4394-b218-ed72fb12f732 (old id 1181786)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18586376?dopt=Abstract
date added to LUP
2008-08-06 10:57:05
date last changed
2017-08-06 04:44:21
@article{3a4b07c5-65df-4394-b218-ed72fb12f732,
  abstract     = {Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and embryonic stem cells, to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease.},
  author       = {Deierborg, Tomas and Soulet, Denis and Roybon, Laurent and Hall, Vanessa and Brundin, Patrik},
  issn         = {1873-5118},
  language     = {eng},
  pages        = {407--432},
  publisher    = {Elsevier},
  series       = {Progress in Neurobiology},
  title        = {Emerging restorative treatments for Parkinson's disease.},
  url          = {http://dx.doi.org/10.1016/j.pneurobio.2008.05.001},
  volume       = {85},
  year         = {2008},
}