Emerging restorative treatments for Parkinson's disease.
(2008) In Progress in Neurobiology 85. p.407-432- Abstract
- Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and... (More)
- Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and embryonic stem cells, to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1181786
- author
- Deierborg, Tomas LU ; Soulet, Denis LU ; Roybon, Laurent LU ; Hall, Vanessa LU and Brundin, Patrik LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Progress in Neurobiology
- volume
- 85
- pages
- 407 - 432
- publisher
- Elsevier
- external identifiers
-
- wos:000259047900004
- pmid:18586376
- scopus:48549096880
- pmid:18586376
- ISSN
- 1873-5118
- DOI
- 10.1016/j.pneurobio.2008.05.001
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- 3a4b07c5-65df-4394-b218-ed72fb12f732 (old id 1181786)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18586376?dopt=Abstract
- date added to LUP
- 2016-04-04 07:23:24
- date last changed
- 2022-01-29 02:05:52
@article{3a4b07c5-65df-4394-b218-ed72fb12f732,
abstract = {{Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and embryonic stem cells, to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease.}},
author = {{Deierborg, Tomas and Soulet, Denis and Roybon, Laurent and Hall, Vanessa and Brundin, Patrik}},
issn = {{1873-5118}},
language = {{eng}},
pages = {{407--432}},
publisher = {{Elsevier}},
series = {{Progress in Neurobiology}},
title = {{Emerging restorative treatments for Parkinson's disease.}},
url = {{http://dx.doi.org/10.1016/j.pneurobio.2008.05.001}},
doi = {{10.1016/j.pneurobio.2008.05.001}},
volume = {{85}},
year = {{2008}},
}