Advanced

Hospitalization for vascular complications in childhood onset type 1 diabetes - effects of gender and age at onset

Dahlquist, G; Mollsten, A and Källén, Bengt LU (2008) In Acta Pædiatrica 97(4). p.483-488
Abstract
Aims: To study the cumulative incidence of hospitalization for severe diabetic vascular complications in childhood onset type 1 diabetes patients with special regards to age at onset and gender. Methods: The Swedish Childhood Diabetes Register (SCDR) was linked to the Swedish Hospital Discharge Register up to 31 December 2004. The following diagnoses were traced: diabetic kidney disease, myocardial infarction, stroke, lower limb arterial disease and diabetes with multiple complications. Cox proportional hazards survival method was applied with the following covariates: maternal age, birthweight deviation from gestational week standard, age at onset and gender. Results: Until 31 December 9974 children had been followed for at least 10 years... (More)
Aims: To study the cumulative incidence of hospitalization for severe diabetic vascular complications in childhood onset type 1 diabetes patients with special regards to age at onset and gender. Methods: The Swedish Childhood Diabetes Register (SCDR) was linked to the Swedish Hospital Discharge Register up to 31 December 2004. The following diagnoses were traced: diabetic kidney disease, myocardial infarction, stroke, lower limb arterial disease and diabetes with multiple complications. Cox proportional hazards survival method was applied with the following covariates: maternal age, birthweight deviation from gestational week standard, age at onset and gender. Results: Until 31 December 9974 children had been followed for at least 10 years corresponding to 141 839 person years at risk and 103 (7.3 per 1000 person years) had been hospitalized at least once at the maximum duration of follow-up of 26 years. Diabetic kidney disease was the most common cause of hospitalization and 63 patients had more than one diabetic complication. Female gender (RR = 2.02, 95% CI = 1.05-3.89) and age at onset of diabetes (RR = 1.37, 95% CI = 1.20-1.56) were significant risk factors for severe complication. Conclusions: Hospitalization for severe diabetic complications at a maximum follow-up of 26 years is rather low in Sweden. There is a higher hospitalization rate among females than among males, and also among patients diagnosed with diabetes after 10 years of age than among patients diagnosed before the age of 10 years. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
complications, vascular, type 1 diabetes, nephropathy, age at onset, gender
in
Acta Pædiatrica
volume
97
issue
4
pages
483 - 488
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000254272000024
  • scopus:41149170767
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2008.00680.x
language
English
LU publication?
yes
id
b8bcff51-68c9-400c-9317-5112daee3a2a (old id 1185178)
date added to LUP
2008-09-03 09:19:59
date last changed
2017-05-07 03:45:25
@article{b8bcff51-68c9-400c-9317-5112daee3a2a,
  abstract     = {Aims: To study the cumulative incidence of hospitalization for severe diabetic vascular complications in childhood onset type 1 diabetes patients with special regards to age at onset and gender. Methods: The Swedish Childhood Diabetes Register (SCDR) was linked to the Swedish Hospital Discharge Register up to 31 December 2004. The following diagnoses were traced: diabetic kidney disease, myocardial infarction, stroke, lower limb arterial disease and diabetes with multiple complications. Cox proportional hazards survival method was applied with the following covariates: maternal age, birthweight deviation from gestational week standard, age at onset and gender. Results: Until 31 December 9974 children had been followed for at least 10 years corresponding to 141 839 person years at risk and 103 (7.3 per 1000 person years) had been hospitalized at least once at the maximum duration of follow-up of 26 years. Diabetic kidney disease was the most common cause of hospitalization and 63 patients had more than one diabetic complication. Female gender (RR = 2.02, 95% CI = 1.05-3.89) and age at onset of diabetes (RR = 1.37, 95% CI = 1.20-1.56) were significant risk factors for severe complication. Conclusions: Hospitalization for severe diabetic complications at a maximum follow-up of 26 years is rather low in Sweden. There is a higher hospitalization rate among females than among males, and also among patients diagnosed with diabetes after 10 years of age than among patients diagnosed before the age of 10 years.},
  author       = {Dahlquist, G and Mollsten, A and Källén, Bengt},
  issn         = {1651-2227},
  keyword      = {complications,vascular,type 1 diabetes,nephropathy,age at onset,gender},
  language     = {eng},
  number       = {4},
  pages        = {483--488},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Hospitalization for vascular complications in childhood onset type 1 diabetes - effects of gender and age at onset},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2008.00680.x},
  volume       = {97},
  year         = {2008},
}