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Multicenter study on deep brain stimulation in Parkinson's disease: An independent assessment of reported adverse events at 4 years

Hariz, Marwan I; Rehncrona, Stig LU ; Quinn, Niall P; Speelman, Johannes D and Wensing, Carin (2008) In Movement Disorders 23(3). p.416-421
Abstract
Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected... (More)
Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
subthalamic nucleus, disease, Parkinson's, globus pallidus, adverse event, deep brain stimulation
in
Movement Disorders
volume
23
issue
3
pages
416 - 421
publisher
John Wiley & Sons
external identifiers
  • wos:000253925700014
  • scopus:43049175254
ISSN
0885-3185
DOI
10.1002/mds.21888
language
English
LU publication?
yes
id
9b556089-2540-4779-9970-c6c78626c7f8 (old id 1185959)
date added to LUP
2008-09-03 11:32:44
date last changed
2017-10-22 03:40:22
@article{9b556089-2540-4779-9970-c6c78626c7f8,
  abstract     = {Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.},
  author       = {Hariz, Marwan I and Rehncrona, Stig and Quinn, Niall P and Speelman, Johannes D and Wensing, Carin},
  issn         = {0885-3185},
  keyword      = {subthalamic nucleus,disease,Parkinson's,globus pallidus,adverse event,deep brain stimulation},
  language     = {eng},
  number       = {3},
  pages        = {416--421},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Multicenter study on deep brain stimulation in Parkinson's disease: An independent assessment of reported adverse events at 4 years},
  url          = {http://dx.doi.org/10.1002/mds.21888},
  volume       = {23},
  year         = {2008},
}