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Development of screening guidelines and clinical criteria for predementia Alzheimer's disease

Visser, P. J.; Verhey, F. R. J.; Boada, M.; Bullock, R.; De Deyn, P. P.; Frisoni, G. B.; Froelich, L.; Hampel, H.; Jolles, J. and Jones, R., et al. (2008) In Neuroepidemiology 30(4). p.254-265
Abstract
Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected,... (More)
Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2 - 3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4. (Less)
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publication status
published
subject
keywords
Alzheimer's disease, elderly, mild cognitive impairment, diagnosis, study, longitudinal cohort, observational, multicentre
in
Neuroepidemiology
volume
30
issue
4
pages
254 - 265
publisher
Karger
external identifiers
  • wos:000257115000009
  • scopus:45749113411
ISSN
1423-0208
DOI
10.1159/000135644
language
English
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yes
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da3a8f40-9af1-4632-9d02-25bc2e28265f (old id 1186643)
date added to LUP
2008-09-03 15:45:47
date last changed
2017-10-22 03:47:40
@article{da3a8f40-9af1-4632-9d02-25bc2e28265f,
  abstract     = {Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2 - 3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.},
  author       = {Visser, P. J. and Verhey, F. R. J. and Boada, M. and Bullock, R. and De Deyn, P. P. and Frisoni, G. B. and Froelich, L. and Hampel, H. and Jolles, J. and Jones, R. and Minthon, Lennart and Nobili, F. and Rikkert, M. Olde and Ousset, P. -J. and Rigaud, A. -S. and Scheltens, P. and Soininen, H. and Spiru, L. and Touchon, J. and Tsolaki, M. and Vellas, B. and Wahlund, L. -O. and Wilcock, G. and Winblad, B.},
  issn         = {1423-0208},
  keyword      = {Alzheimer's disease,elderly,mild cognitive impairment,diagnosis,study,longitudinal cohort,observational,multicentre},
  language     = {eng},
  number       = {4},
  pages        = {254--265},
  publisher    = {Karger},
  series       = {Neuroepidemiology},
  title        = {Development of screening guidelines and clinical criteria for predementia Alzheimer's disease},
  url          = {http://dx.doi.org/10.1159/000135644},
  volume       = {30},
  year         = {2008},
}