Prediction of Alzheimer's disease using a cerebrospinal fluid pattern of C-terminally truncated beta-amyloid peptides
Hoglund, K ; Hansson, Oskar LU
; Buchhave, Peder
LU
; Zetterberg, H
; Lewczuk, P
; Londos, Elisabet
LU
; Blennow, K
; Minthon, Lennart
LU
and Wiltfang, J
(2008)
In Neurodegenerative Diseases
5(5).
p.268-276
- Abstract
- Background: Identifying individuals at high risk of developing Alzheimer's disease (AD) is important for future therapeutic strategies, and there is a clinical need for diagnostic biomarkers to identify incipient AD. Objective: The aim of the present study was to investigate if the AD-associated A beta peptide pattern recently found in cerebrospinal fluid (CSF) could discriminate between patients with incipient AD and those with stable mild cognitive impairment (MCI) by analyzing CSF from patients with MCI at baseline. Methods: The levels of A beta(1-37,-38,-39,-40,-42) were analyzed by A beta-SDS-PAGE/immunoblot in CSF from 19 healthy controls, 25 patients with stable MCI and from 25 patients with MCI who later developed AD during 4-to... (More)
- Background: Identifying individuals at high risk of developing Alzheimer's disease (AD) is important for future therapeutic strategies, and there is a clinical need for diagnostic biomarkers to identify incipient AD. Objective: The aim of the present study was to investigate if the AD-associated A beta peptide pattern recently found in cerebrospinal fluid (CSF) could discriminate between patients with incipient AD and those with stable mild cognitive impairment (MCI) by analyzing CSF from patients with MCI at baseline. Methods: The levels of A beta(1-37,-38,-39,-40,-42) were analyzed by A beta-SDS-PAGE/immunoblot in CSF from 19 healthy controls, 25 patients with stable MCI and from 25 patients with MCI who later developed AD during 4-to 6-year follow-up. Results:All healthy controls and 20 out of 22 patients who developed AD were correctly classified by their baseline A beta peptide pattern. In 9 out of 25 stable MCI patients, the pattern indicated incipient AD in spite of clinical nonconversion. Interestingly, these individuals had apolipoprotein E genotypes and CSF levels of tau and phospho-tau that are known to be associated with high risk of AD. Conclusion: Altogether, our study reveals the novel finding that the A beta peptide pattern is able to predict AD in patients with MCI with a sensitivity of 91% and specificity of 64%. The specificity would increase to 94% if the high-risk patients in the stable MCI cohort developed AD during extended follow-up. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1186669
- author
- Hoglund, K
; Hansson, Oskar
LU
; Buchhave, Peder
LU
; Zetterberg, H
; Lewczuk, P
; Londos, Elisabet
LU
; Blennow, K
; Minthon, Lennart
LU
and Wiltfang, J
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- mild cognitive impairment, pattern, peptide, cerebrospinal fluid, Alzheimer's disease, beta-amyloid, biomarkers
- in
- Neurodegenerative Diseases
- volume
- 5
- issue
- 5
- pages
- 268 - 276
- publisher
- Karger
- external identifiers
-
- wos:000257097900002
- scopus:44649183443
- pmid:18309230
- ISSN
- 1660-2862
- DOI
- 10.1159/000119457
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Psychiatry/Primary Care/Public Health (013240500)
- id
- da5056df-b21d-4df6-8959-abf345aa79bc (old id 1186669)
- date added to LUP
- 2016-04-01 12:11:25
- date last changed
- 2022-01-27 00:04:16
@article{da5056df-b21d-4df6-8959-abf345aa79bc,
abstract = {{Background: Identifying individuals at high risk of developing Alzheimer's disease (AD) is important for future therapeutic strategies, and there is a clinical need for diagnostic biomarkers to identify incipient AD. Objective: The aim of the present study was to investigate if the AD-associated A beta peptide pattern recently found in cerebrospinal fluid (CSF) could discriminate between patients with incipient AD and those with stable mild cognitive impairment (MCI) by analyzing CSF from patients with MCI at baseline. Methods: The levels of A beta(1-37,-38,-39,-40,-42) were analyzed by A beta-SDS-PAGE/immunoblot in CSF from 19 healthy controls, 25 patients with stable MCI and from 25 patients with MCI who later developed AD during 4-to 6-year follow-up. Results:All healthy controls and 20 out of 22 patients who developed AD were correctly classified by their baseline A beta peptide pattern. In 9 out of 25 stable MCI patients, the pattern indicated incipient AD in spite of clinical nonconversion. Interestingly, these individuals had apolipoprotein E genotypes and CSF levels of tau and phospho-tau that are known to be associated with high risk of AD. Conclusion: Altogether, our study reveals the novel finding that the A beta peptide pattern is able to predict AD in patients with MCI with a sensitivity of 91% and specificity of 64%. The specificity would increase to 94% if the high-risk patients in the stable MCI cohort developed AD during extended follow-up.}},
author = {{Hoglund, K and Hansson, Oskar and Buchhave, Peder and Zetterberg, H and Lewczuk, P and Londos, Elisabet and Blennow, K and Minthon, Lennart and Wiltfang, J}},
issn = {{1660-2862}},
keywords = {{mild cognitive impairment; pattern; peptide; cerebrospinal fluid; Alzheimer's disease; beta-amyloid; biomarkers}},
language = {{eng}},
number = {{5}},
pages = {{268--276}},
publisher = {{Karger}},
series = {{Neurodegenerative Diseases}},
title = {{Prediction of Alzheimer's disease using a cerebrospinal fluid pattern of C-terminally truncated beta-amyloid peptides}},
url = {{http://dx.doi.org/10.1159/000119457}},
doi = {{10.1159/000119457}},
volume = {{5}},
year = {{2008}},
}