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Common sequence variants on 20q11.22 confer melanoma susceptibility

Brown, Kevin M.; MacGregor, Stuart; Montgomery, Grant W.; Craig, David W.; Zhao, Zhen Zhen; Iyadurai, Kelly; Henders, Anjali K.; Homer, Nils; Campbell, Megan J. and Stark, Mitchell, et al. (2008) In Nature Genetics 40(7). p.838-840
Abstract
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
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@article{1bf4feee-69fc-4fe3-807e-08679ccff2fa,
  abstract     = {We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P &lt; 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.},
  author       = {Brown, Kevin M. and MacGregor, Stuart and Montgomery, Grant W. and Craig, David W. and Zhao, Zhen Zhen and Iyadurai, Kelly and Henders, Anjali K. and Homer, Nils and Campbell, Megan J. and Stark, Mitchell and Thomas, Shane and Schmid, Helen and Holland, Elizabeth A. and Gillanders, Elizabeth M. and Duffy, David L. and Maskiell, Judith A. and Jetann, Jodie and Ferguson, Megan and Stephan, Dietrich A. and Cust, Anne E. and Whiteman, David and Green, Adele and Olsson, Håkan and Puig, Susana and Ghiorzo, Paola and Hansson, Johan and Demenais, Florence and Goldstein, Alisa M. and Gruis, Nelleke A. and Elder, David E. and Bishop, Julia Newton and Kefford, Richard F. and Giles, Graham G. and Armstrong, Bruce K. and Aitken, Joanne F. and Hopper, John L. and Martin, Nicholas G. and Trent, Jeffrey M. and Mann, Graham J. and Hayward, Nicholas K.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {7},
  pages        = {838--840},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Common sequence variants on 20q11.22 confer melanoma susceptibility},
  url          = {http://dx.doi.org/10.1038/ng.163},
  volume       = {40},
  year         = {2008},
}