Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

Bonassi, Stefano ; Norppa, Hannu ; Ceppi, Marcello ; Strömberg, Ulf LU ; Vermeulen, Roel ; Znaor, Ariana ; Cebulska-Wasilewska, Antonina ; Fabianova, Eleonora ; Fucic, Alexandra and Gundy, Sarolta , et al. (2008) In Carcinogenesis 29(6). p.1178-1183
Abstract
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified... (More)
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium [RR = 1.31, 95% confidence interval (CI) = 1.07-1.60] and in the high (RR = 1.41; 95% CI = 1.16-1.72) tertiles when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI = 1.34-3.68). The strongest association was found for stomach cancer [RRmedium = 1.17 (95% CI = 0.37-3.70), RRhigh = 3.13 (95% CI = 1.17-8.39)]. Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Carcinogenesis
volume
29
issue
6
pages
1178 - 1183
publisher
Oxford University Press
external identifiers
  • wos:000257398100013
  • scopus:46949084088
  • pmid:18356148
ISSN
0143-3334
DOI
10.1093/carcin/bgn075
language
English
LU publication?
yes
id
670195c7-b592-4fb7-8c2d-9fff6396ea1c (old id 1187082)
date added to LUP
2016-04-01 12:04:19
date last changed
2022-04-29 00:12:31
@article{670195c7-b592-4fb7-8c2d-9fff6396ea1c,
  abstract     = {{Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium [RR = 1.31, 95% confidence interval (CI) = 1.07-1.60] and in the high (RR = 1.41; 95% CI = 1.16-1.72) tertiles when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI = 1.34-3.68). The strongest association was found for stomach cancer [RRmedium = 1.17 (95% CI = 0.37-3.70), RRhigh = 3.13 (95% CI = 1.17-8.39)]. Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type.}},
  author       = {{Bonassi, Stefano and Norppa, Hannu and Ceppi, Marcello and Strömberg, Ulf and Vermeulen, Roel and Znaor, Ariana and Cebulska-Wasilewska, Antonina and Fabianova, Eleonora and Fucic, Alexandra and Gundy, Sarolta and Hansteen, Inger-Lise and Knudsen, Lisbeth E and Lazutka, Juozas and Rossner, Pavel and Sram, Radim J and Boffetta, Paolo}},
  issn         = {{0143-3334}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1178--1183}},
  publisher    = {{Oxford University Press}},
  series       = {{Carcinogenesis}},
  title        = {{Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries}},
  url          = {{http://dx.doi.org/10.1093/carcin/bgn075}},
  doi          = {{10.1093/carcin/bgn075}},
  volume       = {{29}},
  year         = {{2008}},
}