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Acoustophoresis in wet-etched glass chips

Evander, Mikael LU ; Lenshof, Andreas LU ; Laurell, Thomas LU and Nilsson, Johan LU (2008) In Analytical Chemistry 80(13). p.5178-5185
Abstract
Acoustophoresis in microfluidic structures has primarily been reported in silicon microfabricated devices. This paper demonstrates, for the first time, acoustophoresis performed in isotropically etched glass chips providing a performance that matches that of the corresponding silicon microdevices. The resonance mode characteristics of the glass chip were equal to those of the silicon chip at its fundamental resonance. At higher order resonance modes the glass chip displays resonances at lower frequencies than the silicon chip. The cross-sectional profiles of acoustically focused particle streams are also reported for the first time, displaying particles confined in a vertical band in the channel center for both glass and silicon chips. A... (More)
Acoustophoresis in microfluidic structures has primarily been reported in silicon microfabricated devices. This paper demonstrates, for the first time, acoustophoresis performed in isotropically etched glass chips providing a performance that matches that of the corresponding silicon microdevices. The resonance mode characteristics of the glass chip were equal to those of the silicon chip at its fundamental resonance. At higher order resonance modes the glass chip displays resonances at lower frequencies than the silicon chip. The cross-sectional profiles of acoustically focused particle streams are also reported for the first time, displaying particles confined in a vertical band in the channel center for both glass and silicon chips. A particle extraction efficiency of 98% at flow rates up to 200 mu L/min (2% particle concentration) is reported for the glass chip at the fundamental resonance. The glass and silicon chips displayed equal particle extraction performance when tested for increasing particle concentrations of 2-15%, at a flow velocity of 12.9 cm/s for the glass chip and 14.8 cm/s for the silicon chip. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Chemistry
volume
80
issue
13
pages
5178 - 5185
publisher
The American Chemical Society
external identifiers
  • wos:000257270600055
  • scopus:46849105643
ISSN
1520-6882
DOI
10.1021/ac800572n
language
English
LU publication?
yes
id
1ed777ba-87bf-4e3e-8e3c-8d05c1cccd28 (old id 1187189)
date added to LUP
2008-09-05 09:33:48
date last changed
2017-08-06 03:41:13
@article{1ed777ba-87bf-4e3e-8e3c-8d05c1cccd28,
  abstract     = {Acoustophoresis in microfluidic structures has primarily been reported in silicon microfabricated devices. This paper demonstrates, for the first time, acoustophoresis performed in isotropically etched glass chips providing a performance that matches that of the corresponding silicon microdevices. The resonance mode characteristics of the glass chip were equal to those of the silicon chip at its fundamental resonance. At higher order resonance modes the glass chip displays resonances at lower frequencies than the silicon chip. The cross-sectional profiles of acoustically focused particle streams are also reported for the first time, displaying particles confined in a vertical band in the channel center for both glass and silicon chips. A particle extraction efficiency of 98% at flow rates up to 200 mu L/min (2% particle concentration) is reported for the glass chip at the fundamental resonance. The glass and silicon chips displayed equal particle extraction performance when tested for increasing particle concentrations of 2-15%, at a flow velocity of 12.9 cm/s for the glass chip and 14.8 cm/s for the silicon chip.},
  author       = {Evander, Mikael and Lenshof, Andreas and Laurell, Thomas and Nilsson, Johan},
  issn         = {1520-6882},
  language     = {eng},
  number       = {13},
  pages        = {5178--5185},
  publisher    = {The American Chemical Society},
  series       = {Analytical Chemistry},
  title        = {Acoustophoresis in wet-etched glass chips},
  url          = {http://dx.doi.org/10.1021/ac800572n},
  volume       = {80},
  year         = {2008},
}