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In vitro degradation and in vivo biocompatibility study of a new linear poly(urethane urea)

Asplund, Basse; Aulin, Cecilia; Bowden, Tim; Eriksson, Niklas; Mathisen, Torbjörn; Bjursten, Lars Magnus LU and Hilborn, Jöns (2008) In Journal of Biomedical Materials Research. Part B - Applied Biomaterials 86B(1). p.45-55
Abstract
Segmented poly(urethane urea)s (PUUs) with hard segments derived only from methyl 2,6-diisocyantohexanoate (LDI) without the use of a chain extender have previously been described. These materials, which contain hard segments with multiple urea linkages, show exceptionally high strain capability (1600-4700%). In the study reported here, the rate and effect of hydrolysis of these materials were determined for gamma-sterilized and nonsterilized samples. Materials investigated contained PCL, PTMC, P(TMC-co-CL), P(CL-co-DLLA), or P(TMC-co-DLLA) as soft segments and, as well as their mechanical properties, changes in mass, inherent viscosity (IN.), and thermal properties were studied over 20 weeks. Results showed that the degradation rate was... (More)
Segmented poly(urethane urea)s (PUUs) with hard segments derived only from methyl 2,6-diisocyantohexanoate (LDI) without the use of a chain extender have previously been described. These materials, which contain hard segments with multiple urea linkages, show exceptionally high strain capability (1600-4700%). In the study reported here, the rate and effect of hydrolysis of these materials were determined for gamma-sterilized and nonsterilized samples. Materials investigated contained PCL, PTMC, P(TMC-co-CL), P(CL-co-DLLA), or P(TMC-co-DLLA) as soft segments and, as well as their mechanical properties, changes in mass, inherent viscosity (IN.), and thermal properties were studied over 20 weeks. Results showed that the degradation rate was dependant on the soft segment structure, with a higher rate of degradation for the polyester-dominating PUUs exhibiting a substantial loss in IN. A tendency of reduction of tensile strength and strain hardening was seen for all samples. Also, loss in elongation at break was detected, for PUU-P(CL-DLLA) it went from 1600% to 830% in 10 weeks. Gamma radiation caused an initial loss in I.V. and induced more rapid hydrolysis compared with nonsterilized samples, except for PUU-PTMC. A cytotoxicity test using human fibroblasts demonstrated that the material supports cell viability. In addition, an in vivo biocompatibility study showed a typical foreign body reaction after I and 6 weeks. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hydrolysis, mechanical properties, biodegradable, polyurethane, LDI
in
Journal of Biomedical Materials Research. Part B - Applied Biomaterials
volume
86B
issue
1
pages
45 - 55
publisher
John Wiley & Sons
external identifiers
  • wos:000256891600006
  • scopus:45749096962
ISSN
1552-4981
DOI
10.1002/jbm.b.30986
language
English
LU publication?
yes
id
0feb09e8-e2dc-4dd3-96cc-2a162447ac71 (old id 1190650)
date added to LUP
2008-09-08 10:50:41
date last changed
2017-06-11 03:39:04
@article{0feb09e8-e2dc-4dd3-96cc-2a162447ac71,
  abstract     = {Segmented poly(urethane urea)s (PUUs) with hard segments derived only from methyl 2,6-diisocyantohexanoate (LDI) without the use of a chain extender have previously been described. These materials, which contain hard segments with multiple urea linkages, show exceptionally high strain capability (1600-4700%). In the study reported here, the rate and effect of hydrolysis of these materials were determined for gamma-sterilized and nonsterilized samples. Materials investigated contained PCL, PTMC, P(TMC-co-CL), P(CL-co-DLLA), or P(TMC-co-DLLA) as soft segments and, as well as their mechanical properties, changes in mass, inherent viscosity (IN.), and thermal properties were studied over 20 weeks. Results showed that the degradation rate was dependant on the soft segment structure, with a higher rate of degradation for the polyester-dominating PUUs exhibiting a substantial loss in IN. A tendency of reduction of tensile strength and strain hardening was seen for all samples. Also, loss in elongation at break was detected, for PUU-P(CL-DLLA) it went from 1600% to 830% in 10 weeks. Gamma radiation caused an initial loss in I.V. and induced more rapid hydrolysis compared with nonsterilized samples, except for PUU-PTMC. A cytotoxicity test using human fibroblasts demonstrated that the material supports cell viability. In addition, an in vivo biocompatibility study showed a typical foreign body reaction after I and 6 weeks.},
  author       = {Asplund, Basse and Aulin, Cecilia and Bowden, Tim and Eriksson, Niklas and Mathisen, Torbjörn and Bjursten, Lars Magnus and Hilborn, Jöns},
  issn         = {1552-4981},
  keyword      = {hydrolysis,mechanical properties,biodegradable,polyurethane,LDI},
  language     = {eng},
  number       = {1},
  pages        = {45--55},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biomedical Materials Research. Part B - Applied Biomaterials},
  title        = {In vitro degradation and in vivo biocompatibility study of a new linear poly(urethane urea)},
  url          = {http://dx.doi.org/10.1002/jbm.b.30986},
  volume       = {86B},
  year         = {2008},
}