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Smooth, slow and smart muscle motors.

Arner, Anders LU ; Löfgren, Mia and Morano, Ingo (2003) In Journal of Muscle Research and Cell Motility 24(2-3). p.165-173
Abstract
Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative splicing in the myosin heavy chain tail (SM1, SM2 isoforms) and head (SM-A SM-B isoforms) regions, as well as the role of essential light chains (LC17a, LC17b isoforms) for the variability of contractile properties are discussed. Smooth muscle also has the ability to alter its contractile properties in response to altered functional demands in vivo,... (More)
Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative splicing in the myosin heavy chain tail (SM1, SM2 isoforms) and head (SM-A SM-B isoforms) regions, as well as the role of essential light chains (LC17a, LC17b isoforms) for the variability of contractile properties are discussed. Smooth muscle also has the ability to alter its contractile properties in response to altered functional demands in vivo, e.g. during hypertrophic growth of urinary bladder, intestine, uterus and vessels and in response to altered hormone levels. These alterations involve changes in myosin expression and altered contractile kinetics. Non-muscle myosin has been shown to have a contractile function in some smooth muscle tissues and recent data on the kinetic properties of non-muscle myosin filaments in smooth muscle tissue are described. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Muscle Research and Cell Motility
volume
24
issue
2-3
pages
165 - 173
publisher
Springer
external identifiers
  • pmid:14609028
  • wos:000185661000007
  • scopus:0242352478
ISSN
0142-4319
DOI
10.1023/A:1026001513928
language
English
LU publication?
yes
id
0c2bd98b-815a-4355-9994-16391485e7d7 (old id 119072)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14609028&dopt=Abstract
date added to LUP
2007-07-10 09:40:59
date last changed
2017-07-09 04:30:43
@article{0c2bd98b-815a-4355-9994-16391485e7d7,
  abstract     = {Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative splicing in the myosin heavy chain tail (SM1, SM2 isoforms) and head (SM-A SM-B isoforms) regions, as well as the role of essential light chains (LC17a, LC17b isoforms) for the variability of contractile properties are discussed. Smooth muscle also has the ability to alter its contractile properties in response to altered functional demands in vivo, e.g. during hypertrophic growth of urinary bladder, intestine, uterus and vessels and in response to altered hormone levels. These alterations involve changes in myosin expression and altered contractile kinetics. Non-muscle myosin has been shown to have a contractile function in some smooth muscle tissues and recent data on the kinetic properties of non-muscle myosin filaments in smooth muscle tissue are described.},
  author       = {Arner, Anders and Löfgren, Mia and Morano, Ingo},
  issn         = {0142-4319},
  language     = {eng},
  number       = {2-3},
  pages        = {165--173},
  publisher    = {Springer},
  series       = {Journal of Muscle Research and Cell Motility},
  title        = {Smooth, slow and smart muscle motors.},
  url          = {http://dx.doi.org/10.1023/A:1026001513928},
  volume       = {24},
  year         = {2003},
}