Smooth, slow and smart muscle motors.
(2003) In Journal of Muscle Research and Cell Motility 24(2-3). p.165-173- Abstract
- Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative splicing in the myosin heavy chain tail (SM1, SM2 isoforms) and head (SM-A SM-B isoforms) regions, as well as the role of essential light chains (LC17a, LC17b isoforms) for the variability of contractile properties are discussed. Smooth muscle also has the ability to alter its contractile properties in response to altered functional demands in vivo,... (More)
- Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative splicing in the myosin heavy chain tail (SM1, SM2 isoforms) and head (SM-A SM-B isoforms) regions, as well as the role of essential light chains (LC17a, LC17b isoforms) for the variability of contractile properties are discussed. Smooth muscle also has the ability to alter its contractile properties in response to altered functional demands in vivo, e.g. during hypertrophic growth of urinary bladder, intestine, uterus and vessels and in response to altered hormone levels. These alterations involve changes in myosin expression and altered contractile kinetics. Non-muscle myosin has been shown to have a contractile function in some smooth muscle tissues and recent data on the kinetic properties of non-muscle myosin filaments in smooth muscle tissue are described. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/119072
- author
- Arner, Anders LU ; Löfgren, Mia and Morano, Ingo
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Muscle Research and Cell Motility
- volume
- 24
- issue
- 2-3
- pages
- 165 - 173
- publisher
- Springer
- external identifiers
-
- pmid:14609028
- wos:000185661000007
- scopus:0242352478
- ISSN
- 0142-4319
- DOI
- 10.1023/A:1026001513928
- language
- English
- LU publication?
- yes
- id
- 0c2bd98b-815a-4355-9994-16391485e7d7 (old id 119072)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14609028&dopt=Abstract
- date added to LUP
- 2016-04-01 17:15:54
- date last changed
- 2022-04-23 03:52:26
@article{0c2bd98b-815a-4355-9994-16391485e7d7,
abstract = {{Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative splicing in the myosin heavy chain tail (SM1, SM2 isoforms) and head (SM-A SM-B isoforms) regions, as well as the role of essential light chains (LC17a, LC17b isoforms) for the variability of contractile properties are discussed. Smooth muscle also has the ability to alter its contractile properties in response to altered functional demands in vivo, e.g. during hypertrophic growth of urinary bladder, intestine, uterus and vessels and in response to altered hormone levels. These alterations involve changes in myosin expression and altered contractile kinetics. Non-muscle myosin has been shown to have a contractile function in some smooth muscle tissues and recent data on the kinetic properties of non-muscle myosin filaments in smooth muscle tissue are described.}},
author = {{Arner, Anders and Löfgren, Mia and Morano, Ingo}},
issn = {{0142-4319}},
language = {{eng}},
number = {{2-3}},
pages = {{165--173}},
publisher = {{Springer}},
series = {{Journal of Muscle Research and Cell Motility}},
title = {{Smooth, slow and smart muscle motors.}},
url = {{http://dx.doi.org/10.1023/A:1026001513928}},
doi = {{10.1023/A:1026001513928}},
volume = {{24}},
year = {{2003}},
}