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Cholesterol in women at high cardiovascular risk is less successfully treated than in corresponding men

Mehner, Anita; Lindblad, Ulf LU ; Råstam, Lennart LU and Bengtsson Boström, Kristina LU (2008) In European Journal of Clinical Pharmacology 64(8). p.815-820
Abstract
Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on cardiovascular risk including serum total cholesterol. Information on medical history and current medication was collected in structured interviews. Results Eighty-two patients (11.3%) reported a history of CHD, including 51 men and 31 women. Fifty-three patients fulfilled criteria for treatment and most of them (85%) were on lipid-lowering... (More)
Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on cardiovascular risk including serum total cholesterol. Information on medical history and current medication was collected in structured interviews. Results Eighty-two patients (11.3%) reported a history of CHD, including 51 men and 31 women. Fifty-three patients fulfilled criteria for treatment and most of them (85%) were on lipid-lowering therapy. A higher fraction of women were treated; however only 13% of them reached target cholesterol levels compared to 37% of the men (P<0.001). Sixty-five subjects (9.0%) had diabetes and/or a previous stroke (29 men, 36 women) but no previous CHD. Patients with CHD were more likely to be treated compared to patients with diabetes and/or stroke but no CHD (85.0 vs. 28.5%, OR 6.0, 95% CI 2.2-16.9, P=0.01). In a total of 79 participants (10.9%) who were on lipid-lowering therapy, women reached a total serum cholesterol level below 5.0 mmol/L less often than men (26.3 vs. 63.4%, P<0.001). Conclusions A considerable proportion of patients in primary care were untreated despite current guidelines on lipid-lowering therapy. Treatment outcome in women was less efficient compared with men. Strategies to improve pharmacological treatment in these patients should be developed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary heart disease, primary care, lipid-lowering drugs, guidelines, diabetes, cerebrovascular disease
in
European Journal of Clinical Pharmacology
volume
64
issue
8
pages
815 - 820
publisher
Springer
external identifiers
  • wos:000256927900008
  • scopus:45849128695
ISSN
1432-1041
DOI
10.1007/s00228-008-0482-x
language
English
LU publication?
yes
id
80243f9a-9432-414d-8fcc-9e3b39fee28f (old id 1191081)
date added to LUP
2008-09-08 11:18:45
date last changed
2017-01-01 05:47:09
@article{80243f9a-9432-414d-8fcc-9e3b39fee28f,
  abstract     = {Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged &gt;= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on cardiovascular risk including serum total cholesterol. Information on medical history and current medication was collected in structured interviews. Results Eighty-two patients (11.3%) reported a history of CHD, including 51 men and 31 women. Fifty-three patients fulfilled criteria for treatment and most of them (85%) were on lipid-lowering therapy. A higher fraction of women were treated; however only 13% of them reached target cholesterol levels compared to 37% of the men (P&lt;0.001). Sixty-five subjects (9.0%) had diabetes and/or a previous stroke (29 men, 36 women) but no previous CHD. Patients with CHD were more likely to be treated compared to patients with diabetes and/or stroke but no CHD (85.0 vs. 28.5%, OR 6.0, 95% CI 2.2-16.9, P=0.01). In a total of 79 participants (10.9%) who were on lipid-lowering therapy, women reached a total serum cholesterol level below 5.0 mmol/L less often than men (26.3 vs. 63.4%, P&lt;0.001). Conclusions A considerable proportion of patients in primary care were untreated despite current guidelines on lipid-lowering therapy. Treatment outcome in women was less efficient compared with men. Strategies to improve pharmacological treatment in these patients should be developed.},
  author       = {Mehner, Anita and Lindblad, Ulf and Råstam, Lennart and Bengtsson Boström, Kristina},
  issn         = {1432-1041},
  keyword      = {coronary heart disease,primary care,lipid-lowering drugs,guidelines,diabetes,cerebrovascular disease},
  language     = {eng},
  number       = {8},
  pages        = {815--820},
  publisher    = {Springer},
  series       = {European Journal of Clinical Pharmacology},
  title        = {Cholesterol in women at high cardiovascular risk is less successfully treated than in corresponding men},
  url          = {http://dx.doi.org/10.1007/s00228-008-0482-x},
  volume       = {64},
  year         = {2008},
}