Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
(2002) In Diabetes 51(5). p.1346-1355- Abstract
- Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely... (More)
- Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely than females to be negative for GADA (P < 0.0001), autoantibodies to islet cells (P = 0.04), and all four autoantibody markers (P = 0.004). The CTLA-4 3' end microsatellite marker was not associated with any of the autoantibodies. We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/119287
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 51
- issue
- 5
- pages
- 1346 - 1355
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000175492400005
- pmid:11978629
- scopus:0036319041
- ISSN
- 1939-327X
- DOI
- 10.2337/diabetes.51.5.1346
- language
- English
- LU publication?
- yes
- id
- c861f531-f055-4415-ac63-22ecb7342429 (old id 119287)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11978629&dopt=Abstract
- date added to LUP
- 2016-04-01 16:23:37
- date last changed
- 2024-01-11 07:10:48
@article{c861f531-f055-4415-ac63-22ecb7342429, abstract = {{Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely than females to be negative for GADA (P < 0.0001), autoantibodies to islet cells (P = 0.04), and all four autoantibody markers (P = 0.004). The CTLA-4 3' end microsatellite marker was not associated with any of the autoantibodies. We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development.}}, author = {{Graham, J and Hagopian, WA and Kockum, I and Li, LS and Sanjeevi, CB and Lowe, RM and Schaefer, JB and Zarghami, M and Day, HL and Landin-Olsson, Mona and Palmer, JP and Janer-Villanueva, M and Hood, L and Sundkvist, G and Lernmark, Åke and Breslow, N and Dahlquist, G and Blohme, G}}, issn = {{1939-327X}}, language = {{eng}}, number = {{5}}, pages = {{1346--1355}}, publisher = {{American Diabetes Association Inc.}}, series = {{Diabetes}}, title = {{Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.}}, url = {{http://dx.doi.org/10.2337/diabetes.51.5.1346}}, doi = {{10.2337/diabetes.51.5.1346}}, volume = {{51}}, year = {{2002}}, }