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Intranasal selective brain cooling in pigs

Covaciu, L; Allers, M.; Enblad, P; Lunderquist, Anders LU ; Wieloch, Tadeusz LU and Rubertsson, S (2008) In Resuscitation 76(1). p.83-88
Abstract
Background: Special clinical situations where general hypothermia cannot be recommended but can be a useful treatment demand a new approach, selective brain cooling. The purpose of this study was to selectively cool the brain with cold saline circulating in balloon catheters introduced into the nasal cavity in pigs. Material and methods: Twelve anaesthetised pigs were subjected to selective cerebral cooling for a period of 6 h. Cerebral temperature was towered by means of bilaterally introduced nasal balloon catheters perfused with saline cooled by a heat exchanger to 8-10 degrees C. Brain temperature was measured in both cerebral hemispheres. Body temperature was measured in rectum, oesophagus and the right atrium. The pigs were... (More)
Background: Special clinical situations where general hypothermia cannot be recommended but can be a useful treatment demand a new approach, selective brain cooling. The purpose of this study was to selectively cool the brain with cold saline circulating in balloon catheters introduced into the nasal cavity in pigs. Material and methods: Twelve anaesthetised pigs were subjected to selective cerebral cooling for a period of 6 h. Cerebral temperature was towered by means of bilaterally introduced nasal balloon catheters perfused with saline cooled by a heat exchanger to 8-10 degrees C. Brain temperature was measured in both cerebral hemispheres. Body temperature was measured in rectum, oesophagus and the right atrium. The pigs were normoventilated and haemodynamic variables were measured continuously. Acid-base and electrolyte status was measured hourly. Results: Cerebral hypothermia was induced rapidly and within the first 20 min of cooling cerebral temperature was lowered from 38.1 +/- 0.6 degrees C by a mean of 2.8 +/- 0.6 to 35.3 +/- 0.6 degrees C. Cooling was maintained for 6 h and the final brain temperature was 34.7 +/- 0.9 degrees C. Concomitantly, the body temperature, as reflected by oesophageal temperature was decreased from 38.3 +/- 0. 5 to 36.6 +/- 0.9 degrees C. No circulatory or metabolic disturbances were noted. Conclusions: Inducing selective brain hypothermia with cold saline via nasal balloon catheters can effectively be accomplished in pigs, with no major disturbances in systemic circulation or physiological variables. The temperature gradients between brain and body can be maintained for at least 6 h. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
selective brain cooling, temperature, hypothermia, cerebral blood flow, cardiac arrest, brain ischaemia, brain injury
in
Resuscitation
volume
76
issue
1
pages
83 - 88
publisher
Elsevier
external identifiers
  • wos:000253204500016
  • scopus:36849047317
ISSN
1873-1570
DOI
10.1016/j.resuscitation.2007.07.002
language
English
LU publication?
yes
id
637b65b3-9fcc-493c-b75a-01ac1d85d82d (old id 1193940)
date added to LUP
2008-09-10 10:23:35
date last changed
2017-01-01 05:11:19
@article{637b65b3-9fcc-493c-b75a-01ac1d85d82d,
  abstract     = {Background: Special clinical situations where general hypothermia cannot be recommended but can be a useful treatment demand a new approach, selective brain cooling. The purpose of this study was to selectively cool the brain with cold saline circulating in balloon catheters introduced into the nasal cavity in pigs. Material and methods: Twelve anaesthetised pigs were subjected to selective cerebral cooling for a period of 6 h. Cerebral temperature was towered by means of bilaterally introduced nasal balloon catheters perfused with saline cooled by a heat exchanger to 8-10 degrees C. Brain temperature was measured in both cerebral hemispheres. Body temperature was measured in rectum, oesophagus and the right atrium. The pigs were normoventilated and haemodynamic variables were measured continuously. Acid-base and electrolyte status was measured hourly. Results: Cerebral hypothermia was induced rapidly and within the first 20 min of cooling cerebral temperature was lowered from 38.1 +/- 0.6 degrees C by a mean of 2.8 +/- 0.6 to 35.3 +/- 0.6 degrees C. Cooling was maintained for 6 h and the final brain temperature was 34.7 +/- 0.9 degrees C. Concomitantly, the body temperature, as reflected by oesophageal temperature was decreased from 38.3 +/- 0. 5 to 36.6 +/- 0.9 degrees C. No circulatory or metabolic disturbances were noted. Conclusions: Inducing selective brain hypothermia with cold saline via nasal balloon catheters can effectively be accomplished in pigs, with no major disturbances in systemic circulation or physiological variables. The temperature gradients between brain and body can be maintained for at least 6 h.},
  author       = {Covaciu, L and Allers, M. and Enblad, P and Lunderquist, Anders and Wieloch, Tadeusz and Rubertsson, S},
  issn         = {1873-1570},
  keyword      = {selective brain cooling,temperature,hypothermia,cerebral blood flow,cardiac arrest,brain ischaemia,brain injury},
  language     = {eng},
  number       = {1},
  pages        = {83--88},
  publisher    = {Elsevier},
  series       = {Resuscitation},
  title        = {Intranasal selective brain cooling in pigs},
  url          = {http://dx.doi.org/10.1016/j.resuscitation.2007.07.002},
  volume       = {76},
  year         = {2008},
}