Immunocytochemical demonstration of estrogen receptor beta in human periodontal ligament cells.
Jönsson, Daniel LU ; Andersson, G ; Ekblad, Eva LU ; Liang, Min LU ; Bratthall, G and Nilsson, Bengt-Olof LU
(2004)
In Archives of Oral Biology
49(1).
p.85-88
- Abstract
- Two transcription associated estrogen receptor (ER) subtypes have been identified and named ERα and ERβ. In the present study we investigate the expression of these ER subtypes in cultured human periodontal ligament (PDL) cells by immunocytochemistry. ERβ immunoreactivity was observed in the nuclei of about 40% of the PDL cells, while no ERα immunoreactivity was detected. In human breast cancer MCF-7 cells, serving as positive controls, both ERα and ERβ immunoreactivities were demonstrated. No immunoreactivity was observed after omission of the primary antibodies. This study suggests that estrogen acts on gene transcription preferentially via ERβ in human PDL cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/119399
- author
- Jönsson, Daniel
LU
; Andersson, G
; Ekblad, Eva
LU
; Liang, Min
LU
; Bratthall, G
and Nilsson, Bengt-Olof
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Periodontal ligament cells, Estrogen receptors, Immunocytochemistry
- in
- Archives of Oral Biology
- volume
- 49
- issue
- 1
- pages
- 85 - 88
- publisher
- Elsevier
- external identifiers
-
- wos:000188418200011
- scopus:0842280811
- ISSN
- 1879-1506
- DOI
- 10.1016/S0003-9969(03)00198-5
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Vascular Physiology (013212034), Neurogastroenterology (013212009)
- id
- 41c8c7a9-64a5-4984-97df-5f2ccff660ae (old id 119399)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14693201&dopt=Abstract
- date added to LUP
- 2016-04-01 12:09:59
- date last changed
- 2022-04-29 01:34:14
@article{41c8c7a9-64a5-4984-97df-5f2ccff660ae,
abstract = {{Two transcription associated estrogen receptor (ER) subtypes have been identified and named ERα and ERβ. In the present study we investigate the expression of these ER subtypes in cultured human periodontal ligament (PDL) cells by immunocytochemistry. ERβ immunoreactivity was observed in the nuclei of about 40% of the PDL cells, while no ERα immunoreactivity was detected. In human breast cancer MCF-7 cells, serving as positive controls, both ERα and ERβ immunoreactivities were demonstrated. No immunoreactivity was observed after omission of the primary antibodies. This study suggests that estrogen acts on gene transcription preferentially via ERβ in human PDL cells.}},
author = {{Jönsson, Daniel and Andersson, G and Ekblad, Eva and Liang, Min and Bratthall, G and Nilsson, Bengt-Olof}},
issn = {{1879-1506}},
keywords = {{Periodontal ligament cells; Estrogen receptors; Immunocytochemistry}},
language = {{eng}},
number = {{1}},
pages = {{85--88}},
publisher = {{Elsevier}},
series = {{Archives of Oral Biology}},
title = {{Immunocytochemical demonstration of estrogen receptor beta in human periodontal ligament cells.}},
url = {{http://dx.doi.org/10.1016/S0003-9969(03)00198-5}},
doi = {{10.1016/S0003-9969(03)00198-5}},
volume = {{49}},
year = {{2004}},
}