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Profound inhibition of chronic itch induced by stimulation of thin cutaneous nerve fibres.

Nilsson, H-J; Psouni, Elia LU ; Carstam, Ragnar LU and Schouenborg, Jens LU (2004) In Journal of the European Academy of Dermatology and Venereology 18(1). p.37-43
Abstract
Background Despite the fact that severe itch is common in many dermatological diseases, the therapeutic arsenal against itching is limited. From neurophysiological experiments, using a new technique termed cutaneous field stimulation, it is known that acute itch can be effectively relieved by stimulation of cutaneous nociceptors.



Methods We tested the effects of cutaneous field stimulation (25 min, 16 electrodes, 4 Hz per electrode, up to 0.8 mA) on chronic itch due to atopic dermatitis. Transcutaneous electrical nerve stimulation (100 Hz, up to 26 mA) was used for comparison. In 27 patients, itch was measured just prior to, during and at regular intervals up to 12 h after either type of treatment.



... (More)
Background Despite the fact that severe itch is common in many dermatological diseases, the therapeutic arsenal against itching is limited. From neurophysiological experiments, using a new technique termed cutaneous field stimulation, it is known that acute itch can be effectively relieved by stimulation of cutaneous nociceptors.



Methods We tested the effects of cutaneous field stimulation (25 min, 16 electrodes, 4 Hz per electrode, up to 0.8 mA) on chronic itch due to atopic dermatitis. Transcutaneous electrical nerve stimulation (100 Hz, up to 26 mA) was used for comparison. In 27 patients, itch was measured just prior to, during and at regular intervals up to 12 h after either type of treatment.



Results Both treatments augmented the itch sensation during ongoing stimulation, presumably reflecting an altered sensory processing in the somatosensory pathways of chronic itch patients. However, after cessation of cutaneous field stimulation, but not transcutaneous electrical nerve stimulation, the itch sensation was significantly depressed for up to 7 h. The peak inhibitory effect (about 25% of control) was reached between 1 and 5 h poststimulation. Neither treatment had any significant effect on alloknesis, as measured before and 10 min after stimulation.



Conclusion It is concluded that cutaneous field stimulation strongly depresses chronic itch, and is a potentially useful symptomatic treatment of itch. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the European Academy of Dermatology and Venereology
volume
18
issue
1
pages
37 - 43
publisher
Elsevier
external identifiers
  • wos:000189150600005
  • pmid:14678529
  • scopus:0842308268
ISSN
1468-3083
DOI
10.1111/j.1468-3083.2004.00724.x
language
English
LU publication?
yes
id
76efcd82-52c0-43b8-93ff-efe943645c78 (old id 119572)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14678529
date added to LUP
2007-07-03 08:49:23
date last changed
2017-06-18 03:40:13
@article{76efcd82-52c0-43b8-93ff-efe943645c78,
  abstract     = {Background Despite the fact that severe itch is common in many dermatological diseases, the therapeutic arsenal against itching is limited. From neurophysiological experiments, using a new technique termed cutaneous field stimulation, it is known that acute itch can be effectively relieved by stimulation of cutaneous nociceptors.<br/><br>
<br/><br>
Methods We tested the effects of cutaneous field stimulation (25 min, 16 electrodes, 4 Hz per electrode, up to 0.8 mA) on chronic itch due to atopic dermatitis. Transcutaneous electrical nerve stimulation (100 Hz, up to 26 mA) was used for comparison. In 27 patients, itch was measured just prior to, during and at regular intervals up to 12 h after either type of treatment.<br/><br>
<br/><br>
Results Both treatments augmented the itch sensation during ongoing stimulation, presumably reflecting an altered sensory processing in the somatosensory pathways of chronic itch patients. However, after cessation of cutaneous field stimulation, but not transcutaneous electrical nerve stimulation, the itch sensation was significantly depressed for up to 7 h. The peak inhibitory effect (about 25% of control) was reached between 1 and 5 h poststimulation. Neither treatment had any significant effect on alloknesis, as measured before and 10 min after stimulation.<br/><br>
<br/><br>
Conclusion It is concluded that cutaneous field stimulation strongly depresses chronic itch, and is a potentially useful symptomatic treatment of itch.},
  author       = {Nilsson, H-J and Psouni, Elia and Carstam, Ragnar and Schouenborg, Jens},
  issn         = {1468-3083},
  language     = {eng},
  number       = {1},
  pages        = {37--43},
  publisher    = {Elsevier},
  series       = {Journal of the European Academy of Dermatology and Venereology},
  title        = {Profound inhibition of chronic itch induced by stimulation of thin cutaneous nerve fibres.},
  url          = {http://dx.doi.org/10.1111/j.1468-3083.2004.00724.x},
  volume       = {18},
  year         = {2004},
}