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Usefulness of computed tomography linear measurements in diagnosing Alzheimer's disease.

Zhang, Yi; Londos, Elisabet LU ; Minthon, Lennart LU ; Wattmo, Carina LU ; Liu, Huaijun; Aspelin, Peter and Wahlund, Lars-Olof (2008) In Acta Radiologica 49(1). p.91-97
Abstract
Background: Medial temporal lobe atrophy (MTA) is an early sign of Alzheimer's disease (AD). The current method of choice for measuring MTA is volumetric measurement based on 3D magnetic resonance imaging (MRI), but this complicated method has not been implemented clinically. Purpose: To investigate whether simple computed tomography (CT) linear measurements of the brain could be of value in AD workup. Material and Methods: Fifty-nine healthy control subjects and 248 AD subjects were recruited. They were evaluated using a comprehensive clinical workup. A series of linear CT measurements were obtained from brain CT. Results: In discriminant analysis, the temporal horn ratio and the suprasellar cistern ratio were the atrophy factors that... (More)
Background: Medial temporal lobe atrophy (MTA) is an early sign of Alzheimer's disease (AD). The current method of choice for measuring MTA is volumetric measurement based on 3D magnetic resonance imaging (MRI), but this complicated method has not been implemented clinically. Purpose: To investigate whether simple computed tomography (CT) linear measurements of the brain could be of value in AD workup. Material and Methods: Fifty-nine healthy control subjects and 248 AD subjects were recruited. They were evaluated using a comprehensive clinical workup. A series of linear CT measurements were obtained from brain CT. Results: In discriminant analysis, the temporal horn ratio and the suprasellar cistern ratio were the atrophy factors that contributed most significantly to the diagnoses. Combined with other clinical factors (apolipoprotein E4 genotype), a correct AD classification of 90.2% was achieved. Conclusion: CT linear measurements could be of value in the workup of AD patients, considering the inexpensiveness and availability of CT as well as the simplicity of linear measurements. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
measures, discriminant analysis, diagnosis, computed tomography, Alzheimer's disease, atrophy
in
Acta Radiologica
volume
49
issue
1
pages
91 - 97
publisher
John Wiley & Sons
external identifiers
  • wos:000253315900018
  • scopus:38349183050
ISSN
1600-0455
DOI
10.1080/02841850701753706
language
English
LU publication?
yes
id
309378ca-161d-40f1-b8c4-cdc265d751e1 (old id 1197049)
date added to LUP
2008-09-10 14:02:19
date last changed
2017-01-01 06:10:58
@article{309378ca-161d-40f1-b8c4-cdc265d751e1,
  abstract     = {Background: Medial temporal lobe atrophy (MTA) is an early sign of Alzheimer's disease (AD). The current method of choice for measuring MTA is volumetric measurement based on 3D magnetic resonance imaging (MRI), but this complicated method has not been implemented clinically. Purpose: To investigate whether simple computed tomography (CT) linear measurements of the brain could be of value in AD workup. Material and Methods: Fifty-nine healthy control subjects and 248 AD subjects were recruited. They were evaluated using a comprehensive clinical workup. A series of linear CT measurements were obtained from brain CT. Results: In discriminant analysis, the temporal horn ratio and the suprasellar cistern ratio were the atrophy factors that contributed most significantly to the diagnoses. Combined with other clinical factors (apolipoprotein E4 genotype), a correct AD classification of 90.2% was achieved. Conclusion: CT linear measurements could be of value in the workup of AD patients, considering the inexpensiveness and availability of CT as well as the simplicity of linear measurements.},
  author       = {Zhang, Yi and Londos, Elisabet and Minthon, Lennart and Wattmo, Carina and Liu, Huaijun and Aspelin, Peter and Wahlund, Lars-Olof},
  issn         = {1600-0455},
  keyword      = {measures,discriminant analysis,diagnosis,computed tomography,Alzheimer's disease,atrophy},
  language     = {eng},
  number       = {1},
  pages        = {91--97},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Usefulness of computed tomography linear measurements in diagnosing Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1080/02841850701753706},
  volume       = {49},
  year         = {2008},
}