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The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

Helgadottir, Anna; Thorleifsson, Gudmar; Magnusson, Kristinn P.; Gretarsdottir, Solveig; Steinthorsdottir, Valgerdur; Manolescu, Andrei; Jones, Gregory T.; Rinkel, Gabriel J. E.; Blankensteijn, Jan D. and Ronkainen, Antti, et al. (2008) In Nature Genetics 40(2). p.217-224
Abstract
Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate... (More)
Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases. (Less)
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Nature Genetics
volume
40
issue
2
pages
217 - 224
publisher
Nature Publishing Group
external identifiers
  • wos:000252732900021
  • scopus:38649091662
ISSN
1546-1718
DOI
10.1038/ng.72
language
English
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yes
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64d7be5d-3fcb-4c36-8512-9f667fcf603c (old id 1198933)
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2008-09-10 17:59:41
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2017-09-03 04:11:06
@article{64d7be5d-3fcb-4c36-8512-9f667fcf603c,
  abstract     = {Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.},
  author       = {Helgadottir, Anna and Thorleifsson, Gudmar and Magnusson, Kristinn P. and Gretarsdottir, Solveig and Steinthorsdottir, Valgerdur and Manolescu, Andrei and Jones, Gregory T. and Rinkel, Gabriel J. E. and Blankensteijn, Jan D. and Ronkainen, Antti and Jaaskelainen, Juha E. and Kyo, Yoshiki and Lenk, Guy M. and Sakalihasan, Natzi and Kostulas, Konstantinos and Gottsäter, Anders and Flex, Andrea and Stefansson, Hreinn and Hansen, Torben and Andersen, Gitte and Weinsheimer, Shantel and Borch-Johnsen, Knut and Jorgensen, Torben and Shah, Svati H. and Quyyumi, Arshed A. and Granger, Christopher B. and Reilly, Muredach P. and Austin, Harland and Levey, Allan I. and Vaccarino, Viola and Palsdottir, Ebba and Walters, G. Bragi and Jonsdottir, Thorbjorg and Snorradottir, Steinunn and Magnusdottir, Dana and Gudmundsson, Gudmundur and Ferrell, Robert E. and Sveinbjornsdottir, Sigurlaug and Hernesniemi, Juha and Niemela, Mika and Limet, Raymond and Andersen, Karl and Sigurdsson, Gunnar and Benediktsson, Rafn and Verhoeven, Eric L. G. and Teijink, Joep A. W. and Grobbee, Diederick E. and Rader, Daniel J. and Collier, David A. and Pedersen, Oluf and Pola, Roberto and Hillert, Jan and Lindblad, Bengt and Valdimarsson, Einar M. and Magnadottir, Hulda B. and Wijmenga, Cisca and Tromp, Gerard and Baas, Annette F. and Ruigrok, Ynte M. and van Rij, Andre M. and Kuivaniemi, Helena and Powell, Janet T. and Matthiasson, Stefan E. and Gulcher, Jeffrey R. and Thorgeirsson, Gudmundur and Kong, Augustine and Thorsteinsdottir, Unnur and Stefansson, Kari},
  issn         = {1546-1718},
  language     = {eng},
  number       = {2},
  pages        = {217--224},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm},
  url          = {http://dx.doi.org/10.1038/ng.72},
  volume       = {40},
  year         = {2008},
}