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Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men

Marsell, Richard; Grundberg, Elin; Krajisnik, Tijana; Mallmin, Hans; Karlsson, Magnus LU ; Mellstrom, Dan; Orwoll, Eric; Ohlsson, Claes; Jonsson, Kenneth B and Ljunggren, Osten, et al. (2008) In European Journal of Endocrinology 158(1). p.125-129
Abstract
Objective: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Serum FGF23 is increased at later stages of chronic kidney disease due to chronic hyperphosphatemia and decreased renal clearance. Recent studies also indicate that FGF23 may directly regulate the expression of parathyroid hormone (PTH) in vitro. Therefore, the objective of the current study was to determine the relationship between FGF23, PTH, and other biochemistries in vivo in subjects with no history of renal disease. Design: Serum biochemistries were measured in a subsample of the population-based Swedish part of the MrOS study In total, 1000 Caucasian men aged 70-80 years were randomly selected from the... (More)
Objective: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Serum FGF23 is increased at later stages of chronic kidney disease due to chronic hyperphosphatemia and decreased renal clearance. Recent studies also indicate that FGF23 may directly regulate the expression of parathyroid hormone (PTH) in vitro. Therefore, the objective of the current study was to determine the relationship between FGF23, PTH, and other biochemistries in vivo in subjects with no history of renal disease. Design: Serum biochemistries were measured in a subsample of the population-based Swedish part of the MrOS study In total, 1000 Caucasian men aged 70-80 years were randomly selected from the population. Methods: Intact FGF23, Pi, calcium, albumin, estimated glomerular filtration rate (eGFR, calculated from cystatin C), PTH, and 25(OH)D-3 were measured. Association studies were performed using linear univariate and multivariate regression analyses. Results: The median FGF23 level was 36.6 pg/ml, ranging from 0.63 to 957 pg/ml. There was a significant correlation between log FGF23 and eGFR (r=-0.21; P < 0.00001) and log PTH (r=0.13; P < 0,001). These variables remained as independent predictors of FGF23 in multivariate analysis. In addition, log PTH (beta = 0.082; P < 0.05) and eGFR (beta = 0.090: P < 0.05) were associated with log FGF23 in subjects with eGFR > 60 ml/min. Only eGFR (beta = 0.35; P < 0.0001.) remained as a predictor of log FGF23 in subjects with eGFR < 60 ml/min. Conclusions: Serum FGF23 and PTH are associated in vivo, supporting recent findings that FGF23 directly regulates PTH expression in vitro. Additionally, eGFR is associated with FGF23 in subjects with normal or mildly impaired renal function, indicating that GFR may modulate FGF23 levels independent of serum Pi. (Less)
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Contribution to journal
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published
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European Journal of Endocrinology
volume
158
issue
1
pages
125 - 129
publisher
Society of the European Journal of Endocrinology
external identifiers
  • wos:000252677200017
  • scopus:38949140252
ISSN
1479-683X
DOI
10.1530/EJE-07-0534
language
English
LU publication?
yes
id
fcb5b925-9bb7-4ce8-992e-24469ef1d27d (old id 1199149)
date added to LUP
2008-09-11 10:29:06
date last changed
2017-07-30 03:49:12
@article{fcb5b925-9bb7-4ce8-992e-24469ef1d27d,
  abstract     = {Objective: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Serum FGF23 is increased at later stages of chronic kidney disease due to chronic hyperphosphatemia and decreased renal clearance. Recent studies also indicate that FGF23 may directly regulate the expression of parathyroid hormone (PTH) in vitro. Therefore, the objective of the current study was to determine the relationship between FGF23, PTH, and other biochemistries in vivo in subjects with no history of renal disease. Design: Serum biochemistries were measured in a subsample of the population-based Swedish part of the MrOS study In total, 1000 Caucasian men aged 70-80 years were randomly selected from the population. Methods: Intact FGF23, Pi, calcium, albumin, estimated glomerular filtration rate (eGFR, calculated from cystatin C), PTH, and 25(OH)D-3 were measured. Association studies were performed using linear univariate and multivariate regression analyses. Results: The median FGF23 level was 36.6 pg/ml, ranging from 0.63 to 957 pg/ml. There was a significant correlation between log FGF23 and eGFR (r=-0.21; P &lt; 0.00001) and log PTH (r=0.13; P &lt; 0,001). These variables remained as independent predictors of FGF23 in multivariate analysis. In addition, log PTH (beta = 0.082; P &lt; 0.05) and eGFR (beta = 0.090: P &lt; 0.05) were associated with log FGF23 in subjects with eGFR &gt; 60 ml/min. Only eGFR (beta = 0.35; P &lt; 0.0001.) remained as a predictor of log FGF23 in subjects with eGFR &lt; 60 ml/min. Conclusions: Serum FGF23 and PTH are associated in vivo, supporting recent findings that FGF23 directly regulates PTH expression in vitro. Additionally, eGFR is associated with FGF23 in subjects with normal or mildly impaired renal function, indicating that GFR may modulate FGF23 levels independent of serum Pi.},
  author       = {Marsell, Richard and Grundberg, Elin and Krajisnik, Tijana and Mallmin, Hans and Karlsson, Magnus and Mellstrom, Dan and Orwoll, Eric and Ohlsson, Claes and Jonsson, Kenneth B and Ljunggren, Osten and Larsson, Tobias E.},
  issn         = {1479-683X},
  language     = {eng},
  number       = {1},
  pages        = {125--129},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology},
  title        = {Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men},
  url          = {http://dx.doi.org/10.1530/EJE-07-0534},
  volume       = {158},
  year         = {2008},
}