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Survival in mantle cell lymphoma patients burdened by a second primary malignancy

Abalo, Kossi D. ; Trab, Trine ; Baech, Joachim ; Ekberg, Sara LU ; Pahnke, Simon ; Albertsson-Lindblad, Alexandra LU ; Smedby, Karin E. ; Jerkeman, Mats LU ; Brown, Peter and Larsen, Thomas Stauffer , et al. (2026) In Leukemia and Lymphoma
Abstract

Second primary malignancies (SPMs) increasingly affect mantle cell lymphoma (MCL) survivors. In nationwide Danish and Swedish cohorts (2000–2020), we evaluated overall survival among MCL patients with SPMs versus matched non-lymphoma individuals with comparable malignancies and MCL patients without SPMs, respectively. Of 3094 MCL survivors, 19% in Denmark and 15% in Sweden developed an SPM, with a median of three years from MCL diagnosis to first SPM. MCL patients with SPMs had about double the mortality risk compared with non-lymphoma counterparts (pooled HR 2.1, 95% confidence interval (CI) 1.3–3.5), and worse survival than MCL patients without SPMs (pooled HR 1.6, 95% CI 1.4–1.9). In Swedish MCL patients with SPMs, deaths were... (More)

Second primary malignancies (SPMs) increasingly affect mantle cell lymphoma (MCL) survivors. In nationwide Danish and Swedish cohorts (2000–2020), we evaluated overall survival among MCL patients with SPMs versus matched non-lymphoma individuals with comparable malignancies and MCL patients without SPMs, respectively. Of 3094 MCL survivors, 19% in Denmark and 15% in Sweden developed an SPM, with a median of three years from MCL diagnosis to first SPM. MCL patients with SPMs had about double the mortality risk compared with non-lymphoma counterparts (pooled HR 2.1, 95% confidence interval (CI) 1.3–3.5), and worse survival than MCL patients without SPMs (pooled HR 1.6, 95% CI 1.4–1.9). In Swedish MCL patients with SPMs, deaths were attributed to subsequent hematologic malignancies (9%), solid cancers (14%), primary MCL (23%), non-cancer causes (11%), with 40% still alive. Development of SPMs in MCL is associated with substantially higher mortality, supporting long-term surveillance and proactive management of late complications.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
MCL, second primary malignancy, survival
in
Leukemia and Lymphoma
publisher
Taylor & Francis
external identifiers
  • pmid:41511911
  • scopus:105027955453
ISSN
1042-8194
DOI
10.1080/10428194.2025.2606211
language
English
LU publication?
yes
id
11a0d763-18fa-408b-847d-62d511f8ceeb
date added to LUP
2026-02-25 15:20:21
date last changed
2026-02-25 15:20:59
@article{11a0d763-18fa-408b-847d-62d511f8ceeb,
  abstract     = {{<p>Second primary malignancies (SPMs) increasingly affect mantle cell lymphoma (MCL) survivors. In nationwide Danish and Swedish cohorts (2000–2020), we evaluated overall survival among MCL patients with SPMs versus matched non-lymphoma individuals with comparable malignancies and MCL patients without SPMs, respectively. Of 3094 MCL survivors, 19% in Denmark and 15% in Sweden developed an SPM, with a median of three years from MCL diagnosis to first SPM. MCL patients with SPMs had about double the mortality risk compared with non-lymphoma counterparts (pooled HR 2.1, 95% confidence interval (CI) 1.3–3.5), and worse survival than MCL patients without SPMs (pooled HR 1.6, 95% CI 1.4–1.9). In Swedish MCL patients with SPMs, deaths were attributed to subsequent hematologic malignancies (9%), solid cancers (14%), primary MCL (23%), non-cancer causes (11%), with 40% still alive. Development of SPMs in MCL is associated with substantially higher mortality, supporting long-term surveillance and proactive management of late complications.</p>}},
  author       = {{Abalo, Kossi D. and Trab, Trine and Baech, Joachim and Ekberg, Sara and Pahnke, Simon and Albertsson-Lindblad, Alexandra and Smedby, Karin E. and Jerkeman, Mats and Brown, Peter and Larsen, Thomas Stauffer and Grønbæk, Kirsten and El-Galaly, Tarec Christoffer and Glimelius, Ingrid}},
  issn         = {{1042-8194}},
  keywords     = {{MCL; second primary malignancy; survival}},
  language     = {{eng}},
  publisher    = {{Taylor & Francis}},
  series       = {{Leukemia and Lymphoma}},
  title        = {{Survival in mantle cell lymphoma patients burdened by a second primary malignancy}},
  url          = {{http://dx.doi.org/10.1080/10428194.2025.2606211}},
  doi          = {{10.1080/10428194.2025.2606211}},
  year         = {{2026}},
}