Advanced

Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease

Simonsen, A H; McGuire, J; Podust, V N; Davies, H; Minthon, Lennart LU ; Skoog, I; Andreasen, N; Wallin, A; Waldemar, G and Blennow, K (2008) In Neurobiology of Aging 29(7). p.961-968
Abstract
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n = 95) and population-based healthy controls (n = 72) were analyzed by SELDI-TOF-MS in order to discover and characterize novel candidate biomarker combinations that differentiate AD patients from normal aging in this explorative study. Thirty candidate biomarkers (ROC AUC > 0.7) were discovered that could differentiate patients with AD from healthy controls. Protein sequence determination and positive identification of... (More)
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n = 95) and population-based healthy controls (n = 72) were analyzed by SELDI-TOF-MS in order to discover and characterize novel candidate biomarker combinations that differentiate AD patients from normal aging in this explorative study. Thirty candidate biomarkers (ROC AUC > 0.7) were discovered that could differentiate patients with AD from healthy controls. Protein sequence determination and positive identification of 15 biomarkers revealed potential associations between the identified markers and AD pathogenesis. A multi-marker combination of five peaks could distinguish AD from healthy control individuals with high sensitivity (97%) and specificity (98%). The panel of five markers was tested on a blinded independent data set of 30 AD samples and 28 controls giving 100% sensitivity and 97% specificity. This novel panel of biomarkers could potentially be used to improve the accuracy of diagnosis of AD. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarkers, Alzheimer's disease, SELDI, proteomics, CSF
in
Neurobiology of Aging
volume
29
issue
7
pages
961 - 968
publisher
Elsevier
external identifiers
  • wos:000256457000001
  • scopus:43849111501
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2007.01.011
language
English
LU publication?
yes
id
b2df33f1-a989-4eee-9eef-cc7e2fb42f23 (old id 1201155)
date added to LUP
2008-09-12 15:25:59
date last changed
2017-11-05 03:33:20
@article{b2df33f1-a989-4eee-9eef-cc7e2fb42f23,
  abstract     = {An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n = 95) and population-based healthy controls (n = 72) were analyzed by SELDI-TOF-MS in order to discover and characterize novel candidate biomarker combinations that differentiate AD patients from normal aging in this explorative study. Thirty candidate biomarkers (ROC AUC > 0.7) were discovered that could differentiate patients with AD from healthy controls. Protein sequence determination and positive identification of 15 biomarkers revealed potential associations between the identified markers and AD pathogenesis. A multi-marker combination of five peaks could distinguish AD from healthy control individuals with high sensitivity (97%) and specificity (98%). The panel of five markers was tested on a blinded independent data set of 30 AD samples and 28 controls giving 100% sensitivity and 97% specificity. This novel panel of biomarkers could potentially be used to improve the accuracy of diagnosis of AD.},
  author       = {Simonsen, A H and McGuire, J and Podust, V N and Davies, H and Minthon, Lennart and Skoog, I and Andreasen, N and Wallin, A and Waldemar, G and Blennow, K},
  issn         = {1558-1497},
  keyword      = {biomarkers,Alzheimer's disease,SELDI,proteomics,CSF},
  language     = {eng},
  number       = {7},
  pages        = {961--968},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2007.01.011},
  volume       = {29},
  year         = {2008},
}