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Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus

Seldin, M F; Qi, L; Scherbarth, H R; Tian, C; Ransom, M; Silva, G; Belmont, J W; Gamron, S; Allievi, A and Palatnik, S A, et al. (2008) In Genes and Immunity 9(4). p.389-393
Abstract
Previous studies have demonstrated that in admixed populations, West African ancestry is associated with an increased prevalence of systemic lupus erythematosus (SLE). In the current study, the effect of Amerindian ancestry in SLE was examined in an admixed population in Argentina. The Argentine population is predominantly European with approximately 20% Amerindian admixture, and a very small (<2%) contribution from West Africa. The results indicate that Amerindian admixture in this population is associated with a substantial increase in SLE susceptibility risk (Odds Ratio = 7.94, P = 0.00006). This difference was not due to known demographic factors, including site of collection, age and gender. In addition, there were trends towards... (More)
Previous studies have demonstrated that in admixed populations, West African ancestry is associated with an increased prevalence of systemic lupus erythematosus (SLE). In the current study, the effect of Amerindian ancestry in SLE was examined in an admixed population in Argentina. The Argentine population is predominantly European with approximately 20% Amerindian admixture, and a very small (<2%) contribution from West Africa. The results indicate that Amerindian admixture in this population is associated with a substantial increase in SLE susceptibility risk (Odds Ratio = 7.94, P = 0.00006). This difference was not due to known demographic factors, including site of collection, age and gender. In addition, there were trends towards significance for Amerindian ancestry influencing renal disease, age of onset and anti-SSA antibodies. These studies suggest that populations with Amerindian admixture, like those with West African admixture, should be considered in future studies to identify additional allelic variants that predispose to SLE. (Less)
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Contribution to journal
publication status
published
subject
keywords
autoimmunity, admixture, systemic lupus erythematosus
in
Genes and Immunity
volume
9
issue
4
pages
389 - 393
publisher
Nature Publishing Group
external identifiers
  • wos:000256388500016
  • scopus:44849127667
ISSN
1476-5470
DOI
10.1038/gene.2008.25
language
English
LU publication?
yes
id
c5e795e7-2d5b-4e48-8102-41e15b1d9930 (old id 1201254)
date added to LUP
2008-09-15 09:45:54
date last changed
2017-03-19 03:23:46
@article{c5e795e7-2d5b-4e48-8102-41e15b1d9930,
  abstract     = {Previous studies have demonstrated that in admixed populations, West African ancestry is associated with an increased prevalence of systemic lupus erythematosus (SLE). In the current study, the effect of Amerindian ancestry in SLE was examined in an admixed population in Argentina. The Argentine population is predominantly European with approximately 20% Amerindian admixture, and a very small (&lt;2%) contribution from West Africa. The results indicate that Amerindian admixture in this population is associated with a substantial increase in SLE susceptibility risk (Odds Ratio = 7.94, P = 0.00006). This difference was not due to known demographic factors, including site of collection, age and gender. In addition, there were trends towards significance for Amerindian ancestry influencing renal disease, age of onset and anti-SSA antibodies. These studies suggest that populations with Amerindian admixture, like those with West African admixture, should be considered in future studies to identify additional allelic variants that predispose to SLE.},
  author       = {Seldin, M F and Qi, L and Scherbarth, H R and Tian, C and Ransom, M and Silva, G and Belmont, J W and Gamron, S and Allievi, A and Palatnik, S A and Saurit, V and Paira, S and Graf, C and Guilleron, C and Catoggio, L J and Prigione, C and Berbotto, G A and Garcia, M A and Perandones, C E and Truedsson, Lennart and Abderrahim, H and Battagliotti, C G and Pons-Estel, B A and Alarcon-Riquelme, M E},
  issn         = {1476-5470},
  keyword      = {autoimmunity,admixture,systemic lupus erythematosus},
  language     = {eng},
  number       = {4},
  pages        = {389--393},
  publisher    = {Nature Publishing Group},
  series       = {Genes and Immunity},
  title        = {Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1038/gene.2008.25},
  volume       = {9},
  year         = {2008},
}