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CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Jenab, Mazda; McKay, James D.; Ferrari, Pietro; Biessy, Carine; Laing, Stewart; Capella Munar, Gabriel Maria; Sala, Nuria; Pena, Salvador; Crusius, J. B. A. and Overvad, Kim, et al. (2008) In European Journal of Cancer 44(6). p.774-780
Abstract
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position 160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in some studies. However, very little information exists on the GC risk association of other CDH1 polymorphisms and it is unclear whether any associations may be different by GC anatomical sites or histological types. Thus, a case-control study (cases = 245/controls = 950) nested within the European Prospective Investigation into Cancer... (More)
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position 160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in some studies. However, very little information exists on the GC risk association of other CDH1 polymorphisms and it is unclear whether any associations may be different by GC anatomical sites or histological types. Thus, a case-control study (cases = 245/controls = 950) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort was conducted to assess the GC risk association of eight CDH1 gene polymorphisms. None of the CDH1 polymorphisms or haplotypes analysed were associated with GC risk and no differences of effect were observed by Helicobacter pylori infection status. However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies. (Less)
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published
subject
keywords
Helicobacter pylori, smoking, EPIC, gastric cancer, E-Cadherin, CDH1, gastric adenocarcinoma
in
European Journal of Cancer
volume
44
issue
6
pages
774 - 780
publisher
Elsevier
external identifiers
  • wos:000256577600009
  • scopus:41949087969
ISSN
1879-0852
DOI
10.1016/j.ejca.2008.02.003
language
English
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yes
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b872fecd-8d36-446e-a4d7-7e81f25a59e4 (old id 1201280)
date added to LUP
2008-09-15 09:50:29
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2017-07-09 03:30:18
@article{b872fecd-8d36-446e-a4d7-7e81f25a59e4,
  abstract     = {Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position 160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in some studies. However, very little information exists on the GC risk association of other CDH1 polymorphisms and it is unclear whether any associations may be different by GC anatomical sites or histological types. Thus, a case-control study (cases = 245/controls = 950) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort was conducted to assess the GC risk association of eight CDH1 gene polymorphisms. None of the CDH1 polymorphisms or haplotypes analysed were associated with GC risk and no differences of effect were observed by Helicobacter pylori infection status. However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies.},
  author       = {Jenab, Mazda and McKay, James D. and Ferrari, Pietro and Biessy, Carine and Laing, Stewart and Capella Munar, Gabriel Maria and Sala, Nuria and Pena, Salvador and Crusius, J. B. A. and Overvad, Kim and Jensen, Majken K. and Olsen, Anja and Tjonneland, Anne and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Kaaks, Rudolf and Linseisen, Jakob and Boeing, Heiner and Bergmann, Manuela M. and Trichopoulou, Antonia and Georgila, Christina and Psaltopoulou, Theodora and Mattiello, Amalia and Vineis, Paolo and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Numans, Mattijs E. and Peeters, Petra H. M. and Bueno-de-Mesquita, H. Bas and Lund, Eiliv and Ardanaz, Eva and Sanchez, Maria-Jose and Dorronsoro, Miren and Navarro Sanchez, Carmen and Ramon Quiros, Jose and Hallmans, Goran and Stenling, Roger and Manjer, Jonas and Regner, Sara and Key, Tim and Bingham, Sheila and Khaw, Kay-tee and Slimani, Nadia and Rinaldi, Sabina and Boffetta, Paolo and Carneiro, Fatima and Riboli, Elio and Gonzalez, Carlos},
  issn         = {1879-0852},
  keyword      = {Helicobacter pylori,smoking,EPIC,gastric cancer,E-Cadherin,CDH1,gastric adenocarcinoma},
  language     = {eng},
  number       = {6},
  pages        = {774--780},
  publisher    = {Elsevier},
  series       = {European Journal of Cancer},
  title        = {CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)},
  url          = {http://dx.doi.org/10.1016/j.ejca.2008.02.003},
  volume       = {44},
  year         = {2008},
}