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Reduced full-field electroretinogram (ERG) in a patient treated with methotrexate.

Ponjavic, Vesna LU ; Gränse, Lotta LU ; Bengtsson-Stigmar, Elisabeth LU and Andréasson, Sten LU (2004) In Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00 82(1). p.96-99
Abstract
Purpose: To examine retinal function in a patient with decreased vision possibly due to treatment with methotrexate.



Methods: Ophthalmological examination included testing of visual acuity (VA), fundus inspection, fundus photography and kinetic perimetry. Retinal function was tested objectively with three electrophysiological methods: full-field electroretinography (ERG), multifocal electroretinography (mfERG) and electro-oculography (EOG).



Results: A 13-year-old boy with psoriasis arthritis had been treated with methotrexate on a weekly basis for 8.5 years. After terminating treatment, his VA, which was reduced to 0.3 in both eyes initially, improved during the following 3 years but did not return to... (More)
Purpose: To examine retinal function in a patient with decreased vision possibly due to treatment with methotrexate.



Methods: Ophthalmological examination included testing of visual acuity (VA), fundus inspection, fundus photography and kinetic perimetry. Retinal function was tested objectively with three electrophysiological methods: full-field electroretinography (ERG), multifocal electroretinography (mfERG) and electro-oculography (EOG).



Results: A 13-year-old boy with psoriasis arthritis had been treated with methotrexate on a weekly basis for 8.5 years. After terminating treatment, his VA, which was reduced to 0.3 in both eyes initially, improved during the following 3 years but did not return to normal. No visual field defects were found with kinetic perimetry. The rod and cone responses in the full-field ERG were markedly reduced in b-wave amplitude initially, but grew slowly to nearly normal values 3 years later. After withdrawal of the drug, the mfERG demonstrated normal responses in the macular region. The Arden index in the EOG was normal.



Conclusion: Chronic treatment with methotrexate may affect VA, and may reversibly reduce rod and cone function. In patients who use systemic medication and whose vision is reduced, objective evaluation of retinal function with electrophysiological methods is recommended. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00
volume
82
issue
1
pages
96 - 99
publisher
Wiley-Blackwell
external identifiers
  • pmid:14982050
  • wos:000188409800020
  • scopus:1242275323
ISSN
1395-3907
DOI
10.1046/j.1600-0420.2003.00181.x
language
English
LU publication?
yes
id
e849ca9b-169a-4bb8-bd44-40910f2ac14a (old id 120398)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14982050&dopt=Abstract
date added to LUP
2007-07-09 10:18:47
date last changed
2017-01-01 06:47:53
@article{e849ca9b-169a-4bb8-bd44-40910f2ac14a,
  abstract     = {Purpose: To examine retinal function in a patient with decreased vision possibly due to treatment with methotrexate.<br/><br>
<br/><br>
Methods: Ophthalmological examination included testing of visual acuity (VA), fundus inspection, fundus photography and kinetic perimetry. Retinal function was tested objectively with three electrophysiological methods: full-field electroretinography (ERG), multifocal electroretinography (mfERG) and electro-oculography (EOG).<br/><br>
<br/><br>
Results: A 13-year-old boy with psoriasis arthritis had been treated with methotrexate on a weekly basis for 8.5 years. After terminating treatment, his VA, which was reduced to 0.3 in both eyes initially, improved during the following 3 years but did not return to normal. No visual field defects were found with kinetic perimetry. The rod and cone responses in the full-field ERG were markedly reduced in b-wave amplitude initially, but grew slowly to nearly normal values 3 years later. After withdrawal of the drug, the mfERG demonstrated normal responses in the macular region. The Arden index in the EOG was normal.<br/><br>
<br/><br>
Conclusion: Chronic treatment with methotrexate may affect VA, and may reversibly reduce rod and cone function. In patients who use systemic medication and whose vision is reduced, objective evaluation of retinal function with electrophysiological methods is recommended.},
  author       = {Ponjavic, Vesna and Gränse, Lotta and Bengtsson-Stigmar, Elisabeth and Andréasson, Sten},
  issn         = {1395-3907},
  language     = {eng},
  number       = {1},
  pages        = {96--99},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00},
  title        = {Reduced full-field electroretinogram (ERG) in a patient treated with methotrexate.},
  url          = {http://dx.doi.org/10.1046/j.1600-0420.2003.00181.x},
  volume       = {82},
  year         = {2004},
}